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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-09655-7 http://scihub22266oqcxt.onion/10.1038/s41598-017-09655-7 C5567253!5567253 !28831201     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28831201 &cmd=llinks): Failed to open stream: HTTP request failed! 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BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasion by reversing the epithelial-mesenchymal transition and down-regulating Wnt/?-catenin signalling |pdf=|usr=}}{{28831201 }} gab.com Text BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasion by reversing the epithelial-mesenchymal transition and down-regulating Wnt/ -catenin signalling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28831201 #FOAvip The novel pyrazoline derivative, BHX, has recently been shown to exhibit potent anti-tumour activity by blocking the Wnt/?-catenin signalling pathway. However, its effect on breast cancer growth and invasion are unknown. Our results show that BHX suppresses MDA-MB-231 cell viability and colony formation in a dose-dependent manner, and induces apoptosis and G0/G1 phase arrest. BHX-treated breast cancer cells showed morphological characteristics of cells undergoing apoptosis. Furthermore, BHX inhibited cell migration and invasion, which was associated with increased E-cadherin mRNA and protein expression, and down-regulation of SNAIL and vimentin. In addition, BHX induced the generation of intracellular ROS and decreased ?-catenin protein and mRNA expression. We used a mouse xenograft model to investigate the effects of BHX in vivo, where the growth of MDA-MB-231 xenografted tumours was suppressed in nude mice treated continuously with BHX for 21 days. Finally, the rat plasma concentration of BHX was measured by ultra-performance liquid-chromatography tandem mass spectrometry and the pharmacokinetic parameters of BHX were processed by non-compartmental analysis. In conclusion, BHX merits further study as a novel therapeutic small molecule for the treatment of breast cancer. Twit Text FOAVip BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasion by reversing the epithelial-mesenchymal transition and down-regulating Wnt/ -catenin signalling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28831201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28831201 #FOAvip English Wikipedia <ref>{{Cite pmid|28831201 }}</ref> BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasion by reversing the epithelial-mesenchymal transition and down-regulating Wnt/?-catenin signalling #MMPMID28831201 Bao H ; Zhang Q ; Zhu Z ; Xu H ; Ding F ; Wang M ; Du S ; Du Y ; Yan Z Sci Rep 2017[Aug]; 7 (1 ): 9153 PMID28831201 show ga The novel pyrazoline derivative, BHX, has recently been shown to exhibit potent anti-tumour activity by blocking the Wnt/?-catenin signalling pathway. However, its effect on breast cancer growth and invasion are unknown. Our results show that BHX suppresses MDA-MB-231 cell viability and colony formation in a dose-dependent manner, and induces apoptosis and G0/G1 phase arrest. BHX-treated breast cancer cells showed morphological characteristics of cells undergoing apoptosis. Furthermore, BHX inhibited cell migration and invasion, which was associated with increased E-cadherin mRNA and protein expression, and down-regulation of SNAIL and vimentin. In addition, BHX induced the generation of intracellular ROS and decreased ?-catenin protein and mRNA expression. We used a mouse xenograft model to investigate the effects of BHX in vivo, where the growth of MDA-MB-231 xenografted tumours was suppressed in nude mice treated continuously with BHX for 21 days. Finally, the rat plasma concentration of BHX was measured by ultra-performance liquid-chromatography tandem mass spectrometry and the pharmacokinetic parameters of BHX were processed by non-compartmental analysis. In conclusion, BHX merits further study as a novel therapeutic small molecule for the treatment of breast cancer. |*Down-Regulation [MESH] |Animals [MESH] |Antinematodal Agents/*administration & dosage/pharmacokinetics [MESH] |Breast Neoplasms/*drug therapy/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Dose-Response Relationship, Drug [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasm Invasiveness [MESH] |Pyrazoles/*administration & dosage/pharmacokinetics [MESH] |Rats [MESH] |Treatment Outcome [MESH] |Wnt Signaling Pathway/*drug effects [MESH]BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasi(epmc).pdf DeepDyve Pubget Overpricing