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10.1038/s41598-017-09337-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-09337-4 C5567134!5567134!28827548     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28827548|t=2017. CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock |pdf=|usr=}}{{28827548}} gab.com Text CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28827548 #FOAvip Current biomarkers for sepsis are limited by their non-specificity, short half-life, and insensitive response to therapy. Recently, we have demonstrated that citrullinated histone H3(CitH3) is released into the blood from neutrophil extracellular traps(NETs) in response to severe infection, and CitH3 may be a potential biomarker for sepsis. In the present study, we found that NET components were released in mouse models of both lipopolysaccharide(LPS)-induced shock (LPSS) and hemorrhagic shock (HS). To further quantify CitH3 in the NETs, we established a CitH3 specific enzyme-linked immunosorbent assay. Circulating CitH3 was found to be elevated only in LPSS but not in HS. Importantly, blood CitH3 was detected 30?minutes after LPS insult, and remained elevated for 24?hours (period of the highest mortality). Treatment of endotoxic mice with YW3-56, a peptidylarginine deiminase-2/4 inhibitor, significantly diminished levels of CitH3 in the blood. Interleukin-1? did not respond to LPS early, and interleukin-1? and interleukin-6 fluctuated although they responded to treatment. Procalcitonin reacted to LPS insult late. Compared to CitH3, these biomarkers were non-specifically induced in LPSS and HS. Collectively, our results demonstrate that YW3-56 protects animals from LPSS, and CitH3 is a reliable biomarker due to its early appearance, specificity, duration, and response to therapeutic intervention. Twit Text FOAVip CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28827548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28827548 #FOAvip English Wikipedia <ref>{{Cite pmid|28827548}}</ref> CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock #MMPMID28827548 Pan B; Alam HB; Chong W; Mobley J; Liu B; Deng Q; Liang Y; Wang Y; Chen E; Wang T; Tewari M; Li Y Sci Rep 2017[]; 7 (ä): ä PMID28827548show ga Current biomarkers for sepsis are limited by their non-specificity, short half-life, and insensitive response to therapy. Recently, we have demonstrated that citrullinated histone H3(CitH3) is released into the blood from neutrophil extracellular traps(NETs) in response to severe infection, and CitH3 may be a potential biomarker for sepsis. In the present study, we found that NET components were released in mouse models of both lipopolysaccharide(LPS)-induced shock (LPSS) and hemorrhagic shock (HS). To further quantify CitH3 in the NETs, we established a CitH3 specific enzyme-linked immunosorbent assay. Circulating CitH3 was found to be elevated only in LPSS but not in HS. Importantly, blood CitH3 was detected 30?minutes after LPS insult, and remained elevated for 24?hours (period of the highest mortality). Treatment of endotoxic mice with YW3-56, a peptidylarginine deiminase-2/4 inhibitor, significantly diminished levels of CitH3 in the blood. Interleukin-1? did not respond to LPS early, and interleukin-1? and interleukin-6 fluctuated although they responded to treatment. Procalcitonin reacted to LPS insult late. Compared to CitH3, these biomarkers were non-specifically induced in LPSS and HS. Collectively, our results demonstrate that YW3-56 protects animals from LPSS, and CitH3 is a reliable biomarker due to its early appearance, specificity, duration, and response to therapeutic intervention. äCitH3: a reliable blood biomarker for diagnosis and treatment of endot(epmc).pdf DeepDyve Pubget Overpricing