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10.3389/fphar.2017.00514 http://scihub22266oqcxt.onion/10.3389/fphar.2017.00514 C5566566!5566566 !28871223     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28871223 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Pharmacol 2017 ; 8 (ä): 514 Nephropedia Template TP {{tp|p=28871223 |t=2017. Effects of Enzymatically Depolymerized Low Molecular Weight Heparins on CCl(4)-Induced Liver Fibrosis |pdf=|usr=}}{{28871223 }} gab.com Text Effects of Enzymatically Depolymerized Low Molecular Weight Heparins on CCl(4)-Induced Liver Fibrosis JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=28871223 #FOAvip With regard to identifying the effective components of LMWH drugs curing hepatic fibrosis disease, we carried out a comparative study on the efficacy of enzymatically depolymerized LMWHs on CCl(4) induced mouse liver fibrosis. The results showed that the controlled enzymatic depolymerization conditions resulted in LMWHs with significantly different activities. The LMWH product depolymerized by Heparinase I (I-11) with a Mw of 7160, exhibited a significant advantage in reducing the liver inflammation by suppressing TNF-? and IL-1? secretion, and minimizing hepatic fibrogenesis. The products prepared by only Heparinase II (II-11), and combined Heparinase III and II (III-II-5) showed limited positive effect on hepatic inflammation and fibrosis. On the contrary, the products by combined Heparinase III and I (III-I-9, III-I-5) showed no effect or stimulation effect on the hepatic fibrogenesis. Our results provided the basis for structure-activity relationship insight for inhibition of liver fibrosis activities of LMWHs, which might have significant implications for generic anti-fibrosis disease drug development. Twit Text FOAVip Effects of Enzymatically Depolymerized Low Molecular Weight Heparins on CCl(4)-Induced Liver Fibrosis ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=28871223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28871223 #FOAvip English Wikipedia <ref>{{Cite pmid|28871223 }}</ref> Effects of Enzymatically Depolymerized Low Molecular Weight Heparins on CCl(4)-Induced Liver Fibrosis #MMPMID28871223 Yan Y ; Guan C ; Du S ; Zhu W ; Ji Y ; Su N ; Mei X ; He D ; Lu Y ; Zhang C ; Xing XH Front Pharmacol 2017[]; 8 (ä): 514 PMID28871223 show ga With regard to identifying the effective components of LMWH drugs curing hepatic fibrosis disease, we carried out a comparative study on the efficacy of enzymatically depolymerized LMWHs on CCl(4) induced mouse liver fibrosis. The results showed that the controlled enzymatic depolymerization conditions resulted in LMWHs with significantly different activities. The LMWH product depolymerized by Heparinase I (I-11) with a Mw of 7160, exhibited a significant advantage in reducing the liver inflammation by suppressing TNF-? and IL-1? secretion, and minimizing hepatic fibrogenesis. The products prepared by only Heparinase II (II-11), and combined Heparinase III and II (III-II-5) showed limited positive effect on hepatic inflammation and fibrosis. On the contrary, the products by combined Heparinase III and I (III-I-9, III-I-5) showed no effect or stimulation effect on the hepatic fibrogenesis. Our results provided the basis for structure-activity relationship insight for inhibition of liver fibrosis activities of LMWHs, which might have significant implications for generic anti-fibrosis disease drug development. äEffects of Enzymatically Depolymerized Low Molecular Weight Heparins o(epmc).pdf DeepDyve Pubget Overpricing