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10.1373/clinchem.2016.260117 http://scihub22266oqcxt.onion/10.1373/clinchem.2016.260117 C5564449!5564449!28188231     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chem 2017 ; 63 (4): 915-23 Nephropedia Template TP {{tp|p=28188231|t=2017. Diurnal and Long-Term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion |pdf=|usr=}}{{28188231}} gab.com Text Diurnal and Long-Term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion JO: Clin Chem http://www.kidney.de/pget.php?&tw=1&pmid=28188231 #FOAvip Background: The renal proximal tubule is essential for removing organic solutes and exogenous medications from the circulation. We evaluated diurnal, prandial, and long-term biological variation of four candidate endogenous markers of proximal tubular secretion. Methods: We used liquid chromatography-mass spectrometry to measure plasma and urine concentrations of hippurate (HA), cinnamoylglycine (CMG), indoxyl sulfate (IS), and p-cresol sulfate (PCS) in 25 healthy adults. We measured plasma concentrations of secreted solutes at 13 time points over a 24-hour period, and again after 2 weeks and 14 weeks of follow-up. We further measured 24-hour renal clearances of secreted solutes at baseline, 2 weeks, and 14 weeks. Results: Plasma concentrations of secreted solutes varied over the 24-hour baseline period. Diurnal variation was greatest for HA, followed by CMG, IS, and PCS. Plasma concentrations of HA (P=0.002) and IS (P=0.02), but not CMG and PCS, increased significantly following meals. Long-term intra-individual variation (CVI) in plasma concentrations of secreted solutes over 14 weeks varied from 21.8% for IS to 67.3% for PCS, and exceeded that for plasma creatinine (CVI 7.1%). Variation in 24-hour renal clearances was similar among the secreted solutes (CVA+I 33.6% ? 47.3%) and was lower using pooled plasma samples from each study visit. Conclusions: Plasma concentrations of HA, CMG, IS, and PCS fluctuate within individuals throughout the day and over weeks. Renal clearances of these secreted solutes, which serve as estimates of renal proximal tubule secretion, are also subject to intra-individual biological variation that can be improved by additional plasma measurements. Twit Text FOAVip Diurnal and Long-Term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion ????Clin Chem http://www.kidney.de/pget.php?&tw=1&pmid=28188231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28188231 #FOAvip English Wikipedia <ref>{{Cite pmid|28188231}}</ref> Diurnal and Long-Term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion #MMPMID28188231 Rivara MB; Zelnick LR; Hoofnagle AN; Newitt R; Tracy RP; Kratz M; Weigle DS; Kestenbaum BR Clin Chem 2017[Apr]; 63 (4): 915-23 PMID28188231show ga Background: The renal proximal tubule is essential for removing organic solutes and exogenous medications from the circulation. We evaluated diurnal, prandial, and long-term biological variation of four candidate endogenous markers of proximal tubular secretion. Methods: We used liquid chromatography-mass spectrometry to measure plasma and urine concentrations of hippurate (HA), cinnamoylglycine (CMG), indoxyl sulfate (IS), and p-cresol sulfate (PCS) in 25 healthy adults. We measured plasma concentrations of secreted solutes at 13 time points over a 24-hour period, and again after 2 weeks and 14 weeks of follow-up. We further measured 24-hour renal clearances of secreted solutes at baseline, 2 weeks, and 14 weeks. Results: Plasma concentrations of secreted solutes varied over the 24-hour baseline period. Diurnal variation was greatest for HA, followed by CMG, IS, and PCS. Plasma concentrations of HA (P=0.002) and IS (P=0.02), but not CMG and PCS, increased significantly following meals. Long-term intra-individual variation (CVI) in plasma concentrations of secreted solutes over 14 weeks varied from 21.8% for IS to 67.3% for PCS, and exceeded that for plasma creatinine (CVI 7.1%). Variation in 24-hour renal clearances was similar among the secreted solutes (CVA+I 33.6% ? 47.3%) and was lower using pooled plasma samples from each study visit. Conclusions: Plasma concentrations of HA, CMG, IS, and PCS fluctuate within individuals throughout the day and over weeks. Renal clearances of these secreted solutes, which serve as estimates of renal proximal tubule secretion, are also subject to intra-individual biological variation that can be improved by additional plasma measurements. äDiurnal and Long-Term Variation in Plasma Concentrations and Renal Cle(epmc).pdf DeepDyve Pubget Overpricing