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10.1042/BSR20170340 http://scihub22266oqcxt.onion/10.1042/BSR20170340 C5563539!5563539 !28760843     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28760843 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biosci+Rep 2017 ; 37 (4 ): ä Nephropedia Template TP {{tp|p=28760843 |t=2017. Atorvastatin enhances radiosensitivity in hypoxia-induced prostate cancer cells related with HIF-1? inhibition |pdf=|usr=}}{{28760843 }} gab.com Text Atorvastatin enhances radiosensitivity in hypoxia-induced prostate cancer cells related with HIF-1 inhibition JO: Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28760843 #FOAvip Hypoxia could enhance radioresistance in prostate cancer cells through up-regulating HIF-1?, which could be inhibited by statins in several cancer cells. However, this effect of statins in prostate cancer remains unclear. In the present study, we aim to investigate the effect of atorvastatin on HIF-1? expression and radiosensitivity in prostate cancer cells. The hypoxia-induced human prostate cancer PC3 cells were generated by incubating with 5% O(2) for 24 h. The cell viability and apoptosis were respectively analyzed by cell counting kit-8 (CCK-8) assay and flow cytometry. The HIF-1? protein expression was assessed by Western blotting. HIF-1? expression in PC3 cells was significantly increased after incubating with 5% O(2) for 24 h. The viability of hypoxia-induced PC3 cells was inhibited by a higher dose of irradiation than control cells. The viability of hypoxia-induced PC3 cells were inhibited by astorvastatin with a higher concentration than control cells. Astorvastatin reduced the HIF-1? protein expression in hypoxia-induced PC3 cells, and induced apoptosis of both control and hypoxia-induced cells with and without irradiation. Atorvastatin could enhance radiosensitivity in hypoxia-induced prostate cancer cells, which may be related with inhibition of HIF-1? protein. Twit Text FOAVip Atorvastatin enhances radiosensitivity in hypoxia-induced prostate cancer cells related with HIF-1 inhibition ????Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28760843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28760843 #FOAvip English Wikipedia <ref>{{Cite pmid|28760843 }}</ref> Atorvastatin enhances radiosensitivity in hypoxia-induced prostate cancer cells related with HIF-1? inhibition #MMPMID28760843 Chen B ; Zhang M ; Xing D ; Feng Y Biosci Rep 2017[Aug]; 37 (4 ): ä PMID28760843 show ga Hypoxia could enhance radioresistance in prostate cancer cells through up-regulating HIF-1?, which could be inhibited by statins in several cancer cells. However, this effect of statins in prostate cancer remains unclear. In the present study, we aim to investigate the effect of atorvastatin on HIF-1? expression and radiosensitivity in prostate cancer cells. The hypoxia-induced human prostate cancer PC3 cells were generated by incubating with 5% O(2) for 24 h. The cell viability and apoptosis were respectively analyzed by cell counting kit-8 (CCK-8) assay and flow cytometry. The HIF-1? protein expression was assessed by Western blotting. HIF-1? expression in PC3 cells was significantly increased after incubating with 5% O(2) for 24 h. The viability of hypoxia-induced PC3 cells was inhibited by a higher dose of irradiation than control cells. The viability of hypoxia-induced PC3 cells were inhibited by astorvastatin with a higher concentration than control cells. Astorvastatin reduced the HIF-1? protein expression in hypoxia-induced PC3 cells, and induced apoptosis of both control and hypoxia-induced cells with and without irradiation. Atorvastatin could enhance radiosensitivity in hypoxia-induced prostate cancer cells, which may be related with inhibition of HIF-1? protein. |Apoptosis/drug effects [MESH] |Atorvastatin/*pharmacology [MESH] |Cell Hypoxia [MESH] |Cell Line, Tumor [MESH] |Cell Survival/drug effects/radiation effects [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism [MESH] |Male [MESH] |Prostatic Neoplasms/*metabolism [MESH]Atorvastatin enhances radiosensitivity in hypoxia-induced prostate can(epmc).pdf DeepDyve Pubget Overpricing