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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Postepy+Dermatol+Alergol
2017 ; 34
(4
): 285-294
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The role of regulatory T cells and genes involved in their differentiation in
pathogenesis of selected inflammatory and neoplastic skin diseases Part I: Treg
properties and functions
#MMPMID28951701
Nedoszytko B
; Lange M
; Soko?owska-Wojdy?o M
; Renke J
; Trzonkowski P
; Sobjanek M
; Szczerkowska-Dobosz A
; Niedoszytko M
; Górska A
; Romantowski J
; Skokowski J
; Kalinowski L
; Nowicki R
Postepy Dermatol Alergol
2017[Aug]; 34
(4
): 285-294
PMID28951701
show ga
Regulatory T cells (Treg) can be divided into two types: the natural cells
(tTreg), which arise in the thymus, and the induced cells (iTreg), which are
produced in peripheral tissues during immune response. The most recently
published studies indicate that the supervisory functions of these cells are
weakened in the pathogenesis of autoimmune and neoplastic diseases of the skin.
This may be a result of the domination of other immune cells in the skin, such as
Th1/Th17/Th22 and Tc1 type in psoriasis and Th2 in atopic dermatitis. The
excessive activity of Treg cells can lead to immunosuppression and decrease in
the number of Th1 cells, which promote the development and progression of skin
cancers. In the case of cutaneous T-cell lymphomas, there are suggestions that
tumor progression is associated with the acquisition of the suppressor phenotype
of malignant cells. There is genetic background of Treg dysfunction in skin
disorders. This article describes the types and functions of Treg cells.