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10.1186/s40035-017-0091-7 http://scihub22266oqcxt.onion/10.1186/s40035-017-0091-7 C5559841!5559841!28824801     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transl+Neurodegener 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28824801|t=2017. The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets |pdf=|usr=}}{{28824801}} gab.com Text The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets JO: Transl Neurodegener http://www.kidney.de/pget.php?&tw=1&pmid=28824801 #FOAvip Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid ?-protein (A?) in the leptomeningeal and cortical blood vessels, which is an age-dependent risk factor for intracerebral hemorrhage (ICH), ischemic stroke and contributes to cerebrovascular dysfunction leading to cognitive impairment. However clinical prevention and treatment of the disease is very difficult because of its occult onset and severity of the symptoms. In recent years, many anti-amyloid ? immunotherapies have not demonstrated clinical efficacy in subjects with Alzheimer?s disease (AD), and the failure may be due to the deposition of A? in the cerebrovascular export pathway resulting in further damage to blood vessels and aggravating CAA. So decreased clearance of A? in blood vessels plays a crucial role in the development of CAA and AD, and identification of the molecular pathways involved will provide new targets for treatment. In this review, we mainly describe the mechanisms of A? clearance through vessels, especially in terms of some proteins and receptors involved in this process. Twit Text FOAVip The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets ????Transl Neurodegener http://www.kidney.de/pget.php?&tw=1&pmid=28824801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28824801 #FOAvip English Wikipedia <ref>{{Cite pmid|28824801}}</ref> The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets #MMPMID28824801 Qi Xm; Ma Jf Transl Neurodegener 2017[]; 6 (ä): ä PMID28824801show ga Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid ?-protein (A?) in the leptomeningeal and cortical blood vessels, which is an age-dependent risk factor for intracerebral hemorrhage (ICH), ischemic stroke and contributes to cerebrovascular dysfunction leading to cognitive impairment. However clinical prevention and treatment of the disease is very difficult because of its occult onset and severity of the symptoms. In recent years, many anti-amyloid ? immunotherapies have not demonstrated clinical efficacy in subjects with Alzheimer?s disease (AD), and the failure may be due to the deposition of A? in the cerebrovascular export pathway resulting in further damage to blood vessels and aggravating CAA. So decreased clearance of A? in blood vessels plays a crucial role in the development of CAA and AD, and identification of the molecular pathways involved will provide new targets for treatment. In this review, we mainly describe the mechanisms of A? clearance through vessels, especially in terms of some proteins and receptors involved in this process. äThe role of amyloid beta clearance in cerebral amyloid angiopathy: mor(epmc).pdf DeepDyve Pubget Overpricing