B lymphocytes in renal interstitial fibrosis #MMPMID28210941
Zhu F; Bai X; Chen X
J Cell Commun Signal 2017[Sep]; 11 (3): 213-8 PMID28210941show ga
Fibrosis is defined as an excessive deposition of extracellular matrix (ECM), which leads to the destruction of organ structure and impairment of organ function. Fibrosis occurs not only in kidney but also in lung, liver, heart, and skin. Common pathways of fibrosis are thought to exist. Renal interstitial fibrosis is a complex process that involves multiple molecular signaling and multiple cellular components, in which B cells appear to be one of the emerging important players. B cells may affect fibrosis through cytokine production and through interaction with other cells including fibroblasts, macrophages and T cells. This review summarizes recent research findings of B cells in fibrosis and provides an insight of how the future therapeutics of fibrosis could be developed from a B-cell point of view.
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J+Cell+Commun+Signal 2017 ; 11 (3): 213-8
