Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1097/MAO.0000000000001439 http://scihub22266oqcxt.onion/10.1097/MAO.0000000000001439 C5559190!5559190!28806330     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Otol+Neurotol 2017 ; 38 (8): e224-31 Nephropedia Template TP {{tp|p=28806330|t=2017. NANOCI?Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons |pdf=|usr=}}{{28806330}} gab.com Text NANOCI Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons JO: Otol Neurotol http://www.kidney.de/pget.php?&tw=1&pmid=28806330 #FOAvip Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems). A recently completed, multinational and interdisciplinary project called NANOCI aimed at overcoming current limitations by creating a gapless interface between auditory nerve fibers and the cochlear implant electrode array. This ambitious goal was achieved in vivo by neurotrophin-induced attraction of neurites through an intracochlear gel-nanomatrix onto a modified nanoCI electrode array located in the scala tympani of deafened guinea pigs. Functionally, the gapless interface led to lower stimulation thresholds and a larger dynamic range in vivo, and to reduced stimulation energy requirement (up to fivefold) in an in vitro model using auditory neurons cultured on multi-electrode arrays. In conclusion, the NANOCI project yielded proof of concept that a gapless interface between auditory neurons and cochlear implant electrode arrays is feasible. These findings may be of relevance for the development of future CI systems with better sound quality and performance and lower energy consumption. The present overview/review paper summarizes the NANOCI project history and highlights achievements of the individual work packages. Twit Text FOAVip NANOCI Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons ????Otol Neurotol http://www.kidney.de/pget.php?&tw=1&pmid=28806330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28806330 #FOAvip English Wikipedia <ref>{{Cite pmid|28806330}}</ref> NANOCI?Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons #MMPMID28806330 Senn P; Roccio M; Hahnewald S; Frick C; Kwiatkowska M; Ishikawa M; Bako P; Li H; Edin F; Liu W; Rask-Andersen H; Pyykkö I; Zou J; Mannerström M; Keppner H; Homsy A; Laux E; Llera M; Lellouche JP; Ostrovsky S; Banin E; Gedanken A; Perkas N; Wank U; Wiesmüller KH; Mistrík P; Benav H; Garnham C; Jolly C; Gander F; Ulrich P; Müller M; Löwenheim H Otol Neurotol 2017[Sep]; 38 (8): e224-31 PMID28806330show ga Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems). A recently completed, multinational and interdisciplinary project called NANOCI aimed at overcoming current limitations by creating a gapless interface between auditory nerve fibers and the cochlear implant electrode array. This ambitious goal was achieved in vivo by neurotrophin-induced attraction of neurites through an intracochlear gel-nanomatrix onto a modified nanoCI electrode array located in the scala tympani of deafened guinea pigs. Functionally, the gapless interface led to lower stimulation thresholds and a larger dynamic range in vivo, and to reduced stimulation energy requirement (up to fivefold) in an in vitro model using auditory neurons cultured on multi-electrode arrays. In conclusion, the NANOCI project yielded proof of concept that a gapless interface between auditory neurons and cochlear implant electrode arrays is feasible. These findings may be of relevance for the development of future CI systems with better sound quality and performance and lower energy consumption. The present overview/review paper summarizes the NANOCI project history and highlights achievements of the individual work packages. äNANOCI?Nanotechnology Based Cochlear Implant With Gapless Interface to(epmc).pdf DeepDyve Pubget Overpricing