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10.1038/ni.3580 http://scihub22266oqcxt.onion/10.1038/ni.3580 C5558830!5558830!27695001     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2016 ; 17 (12): 1373-80 Nephropedia Template TP {{tp|p=27695001|t=2016. Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract |pdf=|usr=}}{{27695001}} gab.com Text Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27695001 #FOAvip The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. We found that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29?/? mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages. Mechanistically, we demonstrated that TRIM29 inhibited interferon-regulatory factors and signaling via the transcription factor NF-?B by degrading the adaptor NEMO and that TRIM29 directly bound NEMO and subsequently induced its ubiquitination and proteolytic degradation. These data identify TRIM29 as a key negative regulator of alveolar macrophages and might have important clinical implications for local immunity and immunopathology. Twit Text FOAVip Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27695001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27695001 #FOAvip English Wikipedia <ref>{{Cite pmid|27695001}}</ref> Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract #MMPMID27695001 Xing J; Weng L; Yuan B; Wang Z; Jia L; Jin R; Lu H; Li XC; Liu YJ; Zhang Z Nat Immunol 2016[Dec]; 17 (12): 1373-80 PMID27695001show ga The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. We found that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29?/? mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages. Mechanistically, we demonstrated that TRIM29 inhibited interferon-regulatory factors and signaling via the transcription factor NF-?B by degrading the adaptor NEMO and that TRIM29 directly bound NEMO and subsequently induced its ubiquitination and proteolytic degradation. These data identify TRIM29 as a key negative regulator of alveolar macrophages and might have important clinical implications for local immunity and immunopathology. äIdentification of a role for TRIM29 in the control of innate immunity (epmc).pdf DeepDyve Pubget Overpricing