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10.2217/pgs-2016-0193 http://scihub22266oqcxt.onion/10.2217/pgs-2016-0193 C5558539!5558539 !28346058     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28346058 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28346058 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pharmacogenomics 2017 ; 18 (6 ): 555-570 Nephropedia Template TP {{tp|p=28346058 |t=2017. Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models |pdf=|usr=}}{{28346058 }} gab.com Text Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models JO: Pharmacogenomics http://www.kidney.de/pget.php?&tw=1&pmid=28346058 #FOAvip Inherited genetic variants contribute to risk factors for developing an alcohol use disorder, and polymorphisms may inform precision medicine strategies for treating alcohol addiction. Targeting genetic mutations linked to alcohol phenotypes has provided promising initial evidence for reducing relapse rates in alcoholics. Although successful in some studies, there are conflicting findings and the reports of adverse effects may ultimately limit their clinical utility, suggesting that novel pharmacogenetic targets are necessary to advance precision medicine approaches. Here, we describe promising novel genetic variants derived from preclinical models of alcohol consumption and dependence that may uncover disease mechanisms that drive uncontrolled drinking and identify novel pharmacogenetic targets that facilitate therapeutic intervention for the treatment of alcohol use disorder. Twit Text FOAVip Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models ????Pharmacogenomics http://www.kidney.de/pget.php?&tw=1&pmid=28346058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28346058 #FOAvip English Wikipedia <ref>{{Cite pmid|28346058 }}</ref> Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models #MMPMID28346058 Rinker JA ; Mulholland PJ Pharmacogenomics 2017[Apr]; 18 (6 ): 555-570 PMID28346058 show ga Inherited genetic variants contribute to risk factors for developing an alcohol use disorder, and polymorphisms may inform precision medicine strategies for treating alcohol addiction. Targeting genetic mutations linked to alcohol phenotypes has provided promising initial evidence for reducing relapse rates in alcoholics. Although successful in some studies, there are conflicting findings and the reports of adverse effects may ultimately limit their clinical utility, suggesting that novel pharmacogenetic targets are necessary to advance precision medicine approaches. Here, we describe promising novel genetic variants derived from preclinical models of alcohol consumption and dependence that may uncover disease mechanisms that drive uncontrolled drinking and identify novel pharmacogenetic targets that facilitate therapeutic intervention for the treatment of alcohol use disorder. |*Models, Animal [MESH] |*Pharmacogenomic Testing [MESH] |*Pharmacogenomic Variants [MESH] |*Polymorphism, Single Nucleotide [MESH] |Alcohol-Related Disorders/*drug therapy/*genetics [MESH] |Animals [MESH] |Humans [MESH] |Mutation [MESH] |Neuroimmunomodulation/genetics [MESH] |Potassium Channels/genetics [MESH]Promising pharmacogenetic targets for treating alcohol use disorder: e(epmc).pdf DeepDyve Pubget Overpricing