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10.1016/j.brainresbull.2017.03.009 http://scihub22266oqcxt.onion/10.1016/j.brainresbull.2017.03.009 C5555796!5555796 !28341600     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28341600 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Brain+Res+Bull 2017 ; 133 (ä): 12-30 Nephropedia Template TP {{tp|p=28341600 |t=2017. Metabolic Dysfunction in Parkinson s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism |pdf=|usr=}}{{28341600 }} gab.com Text Metabolic Dysfunction in Parkinson s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism JO: Brain Res Bull http://www.kidney.de/pget.php?&tw=1&pmid=28341600 #FOAvip The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechanisms linking these PD risk factors to neuronal dysfunction are still unclear. Alterations in redox homeostasis and bioenergetics (energy failure) are thought to be central components of neurodegeneration that contribute to the impairment of important homeostatic processes in dopaminergic cells such as protein quality control mechanisms, neurotransmitter release/metabolism, axonal transport of vesicles and cell survival. Importantly, both bioenergetics and redox homeostasis are coupled to neuro-glial central carbon metabolism. We and others have recently established a link between the alterations in central carbon metabolism induced by PD risk factors, redox homeostasis and bioenergetics and their contribution to the survival/death of dopaminergic cells. In this review, we focus on the link between metabolic dysfunction, energy failure and redox imbalance in PD, making an emphasis in the contribution of central carbon (glucose) metabolism. The evidence summarized here strongly supports the consideration of PD as a disorder of cell metabolism. Twit Text FOAVip Metabolic Dysfunction in Parkinson s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism ????Brain Res Bull http://www.kidney.de/pget.php?&tw=1&pmid=28341600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28341600 #FOAvip English Wikipedia <ref>{{Cite pmid|28341600 }}</ref> Metabolic Dysfunction in Parkinson s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism #MMPMID28341600 Anandhan A ; Jacome MS ; Lei S ; Hernandez-Franco P ; Pappa A ; Panayiotidis MI ; Powers R ; Franco R Brain Res Bull 2017[Jul]; 133 (ä): 12-30 PMID28341600 show ga The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechanisms linking these PD risk factors to neuronal dysfunction are still unclear. Alterations in redox homeostasis and bioenergetics (energy failure) are thought to be central components of neurodegeneration that contribute to the impairment of important homeostatic processes in dopaminergic cells such as protein quality control mechanisms, neurotransmitter release/metabolism, axonal transport of vesicles and cell survival. Importantly, both bioenergetics and redox homeostasis are coupled to neuro-glial central carbon metabolism. We and others have recently established a link between the alterations in central carbon metabolism induced by PD risk factors, redox homeostasis and bioenergetics and their contribution to the survival/death of dopaminergic cells. In this review, we focus on the link between metabolic dysfunction, energy failure and redox imbalance in PD, making an emphasis in the contribution of central carbon (glucose) metabolism. The evidence summarized here strongly supports the consideration of PD as a disorder of cell metabolism. |Brain Diseases, Metabolic [MESH] |Brain/metabolism [MESH] |Carbon/metabolism [MESH] |Dopaminergic Neurons/metabolism [MESH] |Energy Metabolism [MESH] |Homeostasis [MESH] |Humans [MESH] |Mitochondria/metabolism [MESH] |Oxidation-Reduction [MESH] |Oxidative Stress/physiology [MESH] |Parkinson Disease/*metabolism [MESH]Metabolic Dysfunction in Parkinson s Disease: Bioenergetics, Redox Hom(epmc).pdf DeepDyve Pubget Overpricing