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10.1146/annurev-immunol-051116-052302 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-051116-052302 C5555230!5555230!28446063     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Immunol 2017 ; 35 (ä): 229-53 Nephropedia Template TP {{tp|p=28446063|t=2017. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities |pdf=|usr=}}{{28446063}} gab.com Text Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28446063 #FOAvip The ability of immune cells to survey tissues and sense pathologic insults and deviations makes them a unique platform for interfacing with the body and disease. With the rapid advancement of synthetic biology, we can now engineer and equip immune cells with new sensors and controllable therapeutic response programs to sense and treat diseases that our natural immune system cannot normally handle. Here we review the current state of engineered immune cell therapeutics and their unique capabilities compared to small molecules and biologics. We then discuss how engineered immune cells are being designed to combat cancer, focusing on how new synthetic biology tools are providing potential ways to overcome the major roadblocks for treatment. Finally, we give a long-term vision for the use of synthetic biology to engineer immune cells as a general sensor-response platform to precisely detect disease, to remodel disease microenvironments, and to treat a potentially wide range of challenging diseases. Twit Text FOAVip Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28446063 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28446063 #FOAvip English Wikipedia <ref>{{Cite pmid|28446063}}</ref> Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities #MMPMID28446063 Roybal KT; Lim WA Annu Rev Immunol 2017[Apr]; 35 (ä): 229-53 PMID28446063show ga The ability of immune cells to survey tissues and sense pathologic insults and deviations makes them a unique platform for interfacing with the body and disease. With the rapid advancement of synthetic biology, we can now engineer and equip immune cells with new sensors and controllable therapeutic response programs to sense and treat diseases that our natural immune system cannot normally handle. Here we review the current state of engineered immune cell therapeutics and their unique capabilities compared to small molecules and biologics. We then discuss how engineered immune cells are being designed to combat cancer, focusing on how new synthetic biology tools are providing potential ways to overcome the major roadblocks for treatment. Finally, we give a long-term vision for the use of synthetic biology to engineer immune cells as a general sensor-response platform to precisely detect disease, to remodel disease microenvironments, and to treat a potentially wide range of challenging diseases. äSynthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic(epmc).pdf DeepDyve Pubget Overpricing