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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 N+Engl+J+Med 2017 ; 376 (11): 1047-53 Nephropedia Template TP
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Vision Loss after Intravitreal Injection of Autologous ?Stem Cells? for AMD #MMPMID28296617
Kuriyan AE; Albini TA; Townsend JH; Rodriguez M; Pandya HK; Leonard RE; Parrott MB; Rosenfeld PJ; Flynn HW; Goldberg JL
N Engl J Med 2017[Mar]; 376 (11): 1047-53 PMID28296617show ga
Adipose tissue?derived ?stem cells? have been increasingly used by ?stem-cell clinics? in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue?derived ?stem cells? at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients? severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients? visual acuity ranged from 20/200 to no light perception.