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10.1007/s12105-017-0803-4 http://scihub22266oqcxt.onion/10.1007/s12105-017-0803-4 C5550402!5550402!28321772     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Head+Neck+Pathol 2017 ; 11 (3): 278-87 Nephropedia Template TP {{tp|p=28321772|t=2017. Paragangliomas of the Head and Neck: An Overview from Diagnosis to Genetics |pdf=|usr=}}{{28321772}} gab.com Text Paragangliomas of the Head and Neck: An Overview from Diagnosis to Genetics JO: Head Neck Pathol http://www.kidney.de/pget.php?&tw=1&pmid=28321772 #FOAvip Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN) and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx. Globally, the diagnosis and morphologic features are the same regardless of anatomic site, however the incidence, frequency of genetic alterations/syndromes and differential diagnosis vary. It is now recognized that nearly 40% of all HN PGLs are hereditary, including a significant subset without a known family history. Now pathologists are central to the evaluation for diagnosis and further management of patients with HNPGLs. Specifically, SDHB immunohistochemical evaluation is an excellent screening tool to detect tumors with alterations in the SDH family of genes that represent the majority of hereditary cases in HNPGL. Similarly, SDHB immunohistochemical analysis allows for screening of PGL syndrome associated tumors (gastrointestinal stromal tumor (GIST), renal cell carcinoma (RCC), and pituitary adenomas) that have now been linked by their overlapping gene alterations. Awareness of the spectrum of these syndromes, and their associated tumors, positions the pathologist to augment patient care and surveillance. Twit Text FOAVip Paragangliomas of the Head and Neck: An Overview from Diagnosis to Genetics ????Head Neck Pathol http://www.kidney.de/pget.php?&tw=1&pmid=28321772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28321772 #FOAvip English Wikipedia <ref>{{Cite pmid|28321772}}</ref> Paragangliomas of the Head and Neck: An Overview from Diagnosis to Genetics #MMPMID28321772 Williams MD Head Neck Pathol 2017[Sep]; 11 (3): 278-87 PMID28321772show ga Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN) and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx. Globally, the diagnosis and morphologic features are the same regardless of anatomic site, however the incidence, frequency of genetic alterations/syndromes and differential diagnosis vary. It is now recognized that nearly 40% of all HN PGLs are hereditary, including a significant subset without a known family history. Now pathologists are central to the evaluation for diagnosis and further management of patients with HNPGLs. Specifically, SDHB immunohistochemical evaluation is an excellent screening tool to detect tumors with alterations in the SDH family of genes that represent the majority of hereditary cases in HNPGL. Similarly, SDHB immunohistochemical analysis allows for screening of PGL syndrome associated tumors (gastrointestinal stromal tumor (GIST), renal cell carcinoma (RCC), and pituitary adenomas) that have now been linked by their overlapping gene alterations. Awareness of the spectrum of these syndromes, and their associated tumors, positions the pathologist to augment patient care and surveillance. äParagangliomas of the Head and Neck: An Overview from Diagnosis to Gen(epmc).pdf DeepDyve Pubget Overpricing