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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Circ+Biomark
2016 ; 5
(ä): 5
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Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with
Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of
Standard Immune Cell Types
#MMPMID28936253
Lepone LM
; Donahue RN
; Grenga I
; Metenou S
; Richards J
; Heery CR
; Madan RA
; Gulley JL
; Schlom J
J Circ Biomark
2016[Jan]; 5
(ä): 5
PMID28936253
show ga
Recent advances in human immunology have led to the identification of novel
immune cell subsets and the biological function of many of these subsets has now
been identified. The recent US Food and Drug Administration approval of several
immunotherapeutics for the treatment of a variety of cancer types and the results
of ongoing immunotherapy clinical studies requires a more thorough interrogation
of the immune system. We report here the use of flow cytometry-based analyses to
identify 123 immune cell subsets of peripheral blood mononuclear cells. The use
of these panels defines multiple differences in younger (< 40 years) vs. older (?
40 years) individuals and between aged-matched apparently healthy individuals and
metastatic cancer patients, aspects not seen in the analysis of the following
standard immune cell types: CD8, CD4, natural killer, natural killer-T,
regulatory T, myeloid derived suppressor cells, conventional dendritic cells
(DCs), plasmacytoid DCs and B cells. The use of these panels identifying 123
immune cell subsets may aid in the identification of patients who may benefit
from immunotherapy, either prior to therapy or early in the immunotherapeutic
regimen, for the treatment of cancer or other chronic or infectious diseases.