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10.1007/s11926-017-0645-9 http://scihub22266oqcxt.onion/10.1007/s11926-017-0645-9 C5545929!5545929!28361334     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Rheumatol+Rep 2017 ; 19 (4): 18 Nephropedia Template TP {{tp|p=28361334|t=2017. Chronic Recurrent Multifocal Osteomyelitis and Related Diseases ? Update on Pathogenesis |pdf=|usr=}}{{28361334}} gab.com Text Chronic Recurrent Multifocal Osteomyelitis and Related Diseases Update on Pathogenesis JO: Curr Rheumatol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28361334 #FOAvip Purpose of the review: We focus on recent advances in the understanding of the genetic, molecular, immunologic and environmental factors implicated in the pathogenesis of autoinflammatory bone diseases including the syndromic and non-syndromic forms of chronic recurrent multifocal osteomyelitis (CRMO). Recent findings: Evidence implicating the IL-1 pathway in the pathogenesis of the Mendelian forms of CRMO is growing. LIPIN2 can regulate the NLRP3 inflammasome by affecting P2×7 receptor activation and intracellular cholesterol can modulate P2×7R currents. Work in a mouse model of CRMO demonstrates that dietary manipulation can alter the microbiome and protect these mice from the development of sterile osteomyelitis in vivo. Summary: Although the genetic and immunologic basis of non-syndromic CRMO remains only partially understood, the IL-1 pathway is central to the pathogenesis in the syndromic autoinflammatory bone disorders. Recent work implicates lipids and the microbiome in sterile osteomyelitis. Twit Text FOAVip Chronic Recurrent Multifocal Osteomyelitis and Related Diseases Update on Pathogenesis ????Curr Rheumatol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28361334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28361334 #FOAvip English Wikipedia <ref>{{Cite pmid|28361334}}</ref> Chronic Recurrent Multifocal Osteomyelitis and Related Diseases ? Update on Pathogenesis #MMPMID28361334 Cox AJ; Zhao Y; Ferguson PJ Curr Rheumatol Rep 2017[Apr]; 19 (4): 18 PMID28361334show ga Purpose of the review: We focus on recent advances in the understanding of the genetic, molecular, immunologic and environmental factors implicated in the pathogenesis of autoinflammatory bone diseases including the syndromic and non-syndromic forms of chronic recurrent multifocal osteomyelitis (CRMO). Recent findings: Evidence implicating the IL-1 pathway in the pathogenesis of the Mendelian forms of CRMO is growing. LIPIN2 can regulate the NLRP3 inflammasome by affecting P2×7 receptor activation and intracellular cholesterol can modulate P2×7R currents. Work in a mouse model of CRMO demonstrates that dietary manipulation can alter the microbiome and protect these mice from the development of sterile osteomyelitis in vivo. Summary: Although the genetic and immunologic basis of non-syndromic CRMO remains only partially understood, the IL-1 pathway is central to the pathogenesis in the syndromic autoinflammatory bone disorders. Recent work implicates lipids and the microbiome in sterile osteomyelitis. äChronic Recurrent Multifocal Osteomyelitis and Related Diseases ? Upda(epmc).pdf DeepDyve Pubget Overpricing