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10.1042/BCJ20160943 http://scihub22266oqcxt.onion/10.1042/BCJ20160943 C5544130!5544130 !28100650     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28100650 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+J 2017 ; 474 (9 ): 1531-1546 Nephropedia Template TP {{tp|p=28100650 |t=2017. Transforming growth factor ? suppresses peroxisome proliferator-activated receptor ? expression via both SMAD binding and novel TGF-? inhibitory elements |pdf=|usr=}}{{28100650 }} gab.com Text Transforming growth factor suppresses peroxisome proliferator-activated receptor expression via both SMAD binding and novel TGF- inhibitory elements JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=28100650 #FOAvip Transforming growth factor ? (TGF-?) contributes to wound healing and, when dysregulated, to pathological fibrosis. TGF-? and the anti-fibrotic nuclear hormone receptor peroxisome proliferator-activated receptor ? (PPAR?) repress each other's expression, and such PPAR? down-regulation is prominent in fibrosis and mediated, via previously unknown SMAD-signaling mechanisms. Here, we show that TGF-? induces the association of SMAD3 with both SMAD4, needed for translocation of the complex into the nucleus, and the essential context-sensitive co-repressors E2F4 and p107. The complex mediates TGF-?-induced repression by binding to regulatory elements in the target promoter. In the PPARG promoter, we found that the SMAD3-SMAD4 complex binds both to a previously unknown consensus TGF-? inhibitory element (TIE) and also to canonical SMAD-binding elements (SBEs). Furthermore, the TIE and SBEs independently mediated the partial repression of PPARG transcription, the first demonstration of a TIE and SBEs functioning within the same promoter. Also, TGF-?-treated fibroblasts contained SMAD complexes that activated a SMAD target gene in addition to those repressing PPARG transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-? represses PPARG transcription, thereby facilitating its own pro-fibrotic activity. Twit Text FOAVip Transforming growth factor suppresses peroxisome proliferator-activated receptor expression via both SMAD binding and novel TGF- inhibitory elements ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=28100650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28100650 #FOAvip English Wikipedia <ref>{{Cite pmid|28100650 }}</ref> Transforming growth factor ? suppresses peroxisome proliferator-activated receptor ? expression via both SMAD binding and novel TGF-? inhibitory elements #MMPMID28100650 Lakshmi SP ; Reddy AT ; Reddy RC Biochem J 2017[Apr]; 474 (9 ): 1531-1546 PMID28100650 show ga Transforming growth factor ? (TGF-?) contributes to wound healing and, when dysregulated, to pathological fibrosis. TGF-? and the anti-fibrotic nuclear hormone receptor peroxisome proliferator-activated receptor ? (PPAR?) repress each other's expression, and such PPAR? down-regulation is prominent in fibrosis and mediated, via previously unknown SMAD-signaling mechanisms. Here, we show that TGF-? induces the association of SMAD3 with both SMAD4, needed for translocation of the complex into the nucleus, and the essential context-sensitive co-repressors E2F4 and p107. The complex mediates TGF-?-induced repression by binding to regulatory elements in the target promoter. In the PPARG promoter, we found that the SMAD3-SMAD4 complex binds both to a previously unknown consensus TGF-? inhibitory element (TIE) and also to canonical SMAD-binding elements (SBEs). Furthermore, the TIE and SBEs independently mediated the partial repression of PPARG transcription, the first demonstration of a TIE and SBEs functioning within the same promoter. Also, TGF-?-treated fibroblasts contained SMAD complexes that activated a SMAD target gene in addition to those repressing PPARG transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-? represses PPARG transcription, thereby facilitating its own pro-fibrotic activity. |Base Sequence [MESH] |Cell Line [MESH] |Down-Regulation [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |PPAR gamma/genetics/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |RNA, Messenger/genetics [MESH] |Signal Transduction [MESH] |Smad3 Protein/*metabolism [MESH] |Smad4 Protein/*metabolism [MESH] |Transcription, Genetic [MESH]Transforming growth factor ? suppresses peroxisome proliferator-activa(epmc).pdf DeepDyve Pubget Overpricing