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10.1016/j.cmet.2017.06.016 http://scihub22266oqcxt.onion/10.1016/j.cmet.2017.06.016 C5543711!5543711!28683298     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2017 ; 26 (1): 94-109 Nephropedia Template TP {{tp|p=28683298|t=2017. Metabolic regulation of T cell longevity and function in tumor immunotherapy |pdf=|usr=}}{{28683298}} gab.com Text Metabolic regulation of T cell longevity and function in tumor immunotherapy JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28683298 #FOAvip Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells are key mediators of tumor destruction and their specificity for tumor-expressed antigens is of paramount importance, but other T cell-intrinsic qualities such as durability, longevity and functionality also play important roles in determining the efficacy of immunotherapy. The cellular energetic pathways that are utilized by T cells play a key role in regulating each of these qualities. Metabolic activity, which both regulates and is regulated by cellular signaling pathways and epigenetics, also profoundly influences the trajectories of T cell differentiation and fate. In this review, we discuss how cell metabolism influences T cell anti-tumor activity, the metabolic qualities of highly-functional T cells and strategies to modulate metabolism for improving the immune response to tumors. Twit Text FOAVip Metabolic regulation of T cell longevity and function in tumor immunotherapy ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28683298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28683298 #FOAvip English Wikipedia <ref>{{Cite pmid|28683298}}</ref> Metabolic regulation of T cell longevity and function in tumor immunotherapy #MMPMID28683298 Kishton RJ; Sukumar M; Restifo NP Cell Metab 2017[Jul]; 26 (1): 94-109 PMID28683298show ga Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells are key mediators of tumor destruction and their specificity for tumor-expressed antigens is of paramount importance, but other T cell-intrinsic qualities such as durability, longevity and functionality also play important roles in determining the efficacy of immunotherapy. The cellular energetic pathways that are utilized by T cells play a key role in regulating each of these qualities. Metabolic activity, which both regulates and is regulated by cellular signaling pathways and epigenetics, also profoundly influences the trajectories of T cell differentiation and fate. In this review, we discuss how cell metabolism influences T cell anti-tumor activity, the metabolic qualities of highly-functional T cells and strategies to modulate metabolism for improving the immune response to tumors. äMetabolic regulation of T cell longevity and function in tumor immunot(epmc).pdf DeepDyve Pubget Overpricing