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10.1002/art.40032 http://scihub22266oqcxt.onion/10.1002/art.40032 C5543686!5543686!28029751     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Rheumatol 2017 ; 69 (5): 1045-53 Nephropedia Template TP {{tp|p=28029751|t=2017. The effect of continuous B cell depletion with rituximab on pathogenic autoantibodies and total IgG levels in ANCA vasculitis |pdf=|usr=}}{{28029751}} gab.com Text The effect of continuous B cell depletion with rituximab on pathogenic autoantibodies and total IgG levels in ANCA vasculitis JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=28029751 #FOAvip Objective: To evaluate the effect of rituximab on pathogenic autoantibodies and total immunoglobulin levels, and to identify serious adverse events, in patients with ANCA vasculitis treated with continuous B cell depletion. Methods: We conducted a retrospective analysis of 239 patients with ANCA vasculitis treated with rituximab-induced continuous B cell depletion. Two treatment cohorts were analyzed: an induction group (n= 53) and a maintenance group (n=237). The change in ANCA titers and total immunoglobulin levels over time were evaluated using mixed-effects models. Risk factors for serious infections during maintenance were evaluated with Poisson regression. Results: During induction, IgG levels fell at a rate of 6% per month (95% CI, 4 to 8%), while ANCA levels declined at 47% per month (95% CI, 42 to 52%) and 48% per month (95% CI, 42 to 54%) for anti-MPO and anti-PR3 titers, respectively. During maintenance treatment, with a median duration of 2.4 (IQR, 1.5- 4.0) years, IgG levels declined at 0.6% per year (95% CI, -0.2 to 1.4%). New significant hypogammaglobulinemia (IgG < 400 mg/dL) during maintenance occurred in 4.6% of patients, all of whom were in the lowest baseline IgG quartile. Serious infections during maintenance occurred at a rate of 0.85 [95% CI, 0.66 to 1.1] per 10 patient years and were independently associated with an IgG level < 400mg/dL. Conclusion: B cell targeted therapy causes a preferential decline in ANCA titers relative to total IgG levels. Despite prolonged maintenance therapy with rituximab, IgG levels remain essentially constant. Serious infections were rare. Twit Text FOAVip The effect of continuous B cell depletion with rituximab on pathogenic autoantibodies and total IgG levels in ANCA vasculitis ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=28029751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28029751 #FOAvip English Wikipedia <ref>{{Cite pmid|28029751}}</ref> The effect of continuous B cell depletion with rituximab on pathogenic autoantibodies and total IgG levels in ANCA vasculitis #MMPMID28029751 Cortazar FB; Pendergraft WF; Wenger J; Owens CT; Laliberte K; Niles JL Arthritis Rheumatol 2017[May]; 69 (5): 1045-53 PMID28029751show ga Objective: To evaluate the effect of rituximab on pathogenic autoantibodies and total immunoglobulin levels, and to identify serious adverse events, in patients with ANCA vasculitis treated with continuous B cell depletion. Methods: We conducted a retrospective analysis of 239 patients with ANCA vasculitis treated with rituximab-induced continuous B cell depletion. Two treatment cohorts were analyzed: an induction group (n= 53) and a maintenance group (n=237). The change in ANCA titers and total immunoglobulin levels over time were evaluated using mixed-effects models. Risk factors for serious infections during maintenance were evaluated with Poisson regression. Results: During induction, IgG levels fell at a rate of 6% per month (95% CI, 4 to 8%), while ANCA levels declined at 47% per month (95% CI, 42 to 52%) and 48% per month (95% CI, 42 to 54%) for anti-MPO and anti-PR3 titers, respectively. During maintenance treatment, with a median duration of 2.4 (IQR, 1.5- 4.0) years, IgG levels declined at 0.6% per year (95% CI, -0.2 to 1.4%). New significant hypogammaglobulinemia (IgG < 400 mg/dL) during maintenance occurred in 4.6% of patients, all of whom were in the lowest baseline IgG quartile. Serious infections during maintenance occurred at a rate of 0.85 [95% CI, 0.66 to 1.1] per 10 patient years and were independently associated with an IgG level < 400mg/dL. Conclusion: B cell targeted therapy causes a preferential decline in ANCA titers relative to total IgG levels. Despite prolonged maintenance therapy with rituximab, IgG levels remain essentially constant. Serious infections were rare. äThe effect of continuous B cell depletion with rituximab on pathogenic(epmc).pdf DeepDyve Pubget Overpricing