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10.1016/j.jaip.2017.05.015 http://scihub22266oqcxt.onion/10.1016/j.jaip.2017.05.015 C5541906!5541906!28689840     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol+Pract 2017 ; 5 (4): 901-8 Nephropedia Template TP {{tp|p=28689840|t=2017. Severe Asthma Phenotypes ? How Should They Guide Evaluation and Treatment?|pdf=|usr=}}{{28689840}} gab.com Text Severe Asthma Phenotypes How Should They Guide Evaluation and Treatment JO: J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=28689840 #FOAvip Although patients with ?severe? asthma tend to be characterized by ongoing symptoms and airway inflammation despite treatment with high doses of inhaled and systemic corticosteroids, there is increasing recognition of marked phenotypic heterogeneity within affected patients. While ?precision medicine? approaches for patients with severe asthma are needed, there are many hurdles that must be overcome in daily practice. The National Heart, Lung and Blood Institute's Severe Asthma Research Program (SARP) has been at the forefront of phenotype discovery in severe asthma for the past decade. SARP, along with other international groups, have described clinical severe asthma phenotypes in both adults and children that can be evaluated in the clinical setting. While these clinical phenotypes provide a good ?starting point? for addressing disease heterogeneity in severe asthma in everyday practice, more efforts are needed to understand how these phenotypes relate to underlying disease mechanisms and pharmacological treatment responses. This review highlights the clinical asthma phenotypes identified to date, their associations with underlying endotypes and potential biomarkers, and remaining knowledge gaps that must be addressed before precision medicine can become a reality for patients with severe asthma. Twit Text FOAVip Severe Asthma Phenotypes How Should They Guide Evaluation and Treatment ????J Allergy Clin Immunol Pract http://www.kidney.de/pget.php?&tw=1&pmid=28689840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28689840 #FOAvip English Wikipedia <ref>{{Cite pmid|28689840}}</ref> Severe Asthma Phenotypes ? How Should They Guide Evaluation and Treatment? #MMPMID28689840 Fitzpatrick AM; Moore WC J Allergy Clin Immunol Pract 2017[Jul]; 5 (4): 901-8 PMID28689840show ga Although patients with ?severe? asthma tend to be characterized by ongoing symptoms and airway inflammation despite treatment with high doses of inhaled and systemic corticosteroids, there is increasing recognition of marked phenotypic heterogeneity within affected patients. While ?precision medicine? approaches for patients with severe asthma are needed, there are many hurdles that must be overcome in daily practice. The National Heart, Lung and Blood Institute's Severe Asthma Research Program (SARP) has been at the forefront of phenotype discovery in severe asthma for the past decade. SARP, along with other international groups, have described clinical severe asthma phenotypes in both adults and children that can be evaluated in the clinical setting. While these clinical phenotypes provide a good ?starting point? for addressing disease heterogeneity in severe asthma in everyday practice, more efforts are needed to understand how these phenotypes relate to underlying disease mechanisms and pharmacological treatment responses. This review highlights the clinical asthma phenotypes identified to date, their associations with underlying endotypes and potential biomarkers, and remaining knowledge gaps that must be addressed before precision medicine can become a reality for patients with severe asthma. äSevere Asthma Phenotypes ? How Should They Guide Evaluation and Treatm(epmc).pdf DeepDyve Pubget Overpricing