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10.1091/mbc.E17-01-0006 http://scihub22266oqcxt.onion/10.1091/mbc.E17-01-0006 C5541835!5541835 !28251923     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28251923 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28251923 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Cell 2017 ; 28 (14 ): 1847-1852 Nephropedia Template TP {{tp|p=28251923 |t=2017. Binding of ZO-1 to ?5?1 integrins regulates the mechanical properties of ?5?1-fibronectin links |pdf=|usr=}}{{28251923 }} gab.com Text Binding of ZO-1 to 5 1 integrins regulates the mechanical properties of 5 1-fibronectin links JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28251923 #FOAvip Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin ?5?1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the ?5?1-fn link is unknown. Here we show that the ?5?1/ZO-1 complex decreases the resistance to force of ?5?1-fn adhesions located at the edge of migrating cell monolayers while also increasing ?5?1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration. Twit Text FOAVip Binding of ZO-1 to 5 1 integrins regulates the mechanical properties of 5 1-fibronectin links ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28251923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28251923 #FOAvip English Wikipedia <ref>{{Cite pmid|28251923 }}</ref> Binding of ZO-1 to ?5?1 integrins regulates the mechanical properties of ?5?1-fibronectin links #MMPMID28251923 González-Tarragó V ; Elosegui-Artola A ; Bazellières E ; Oria R ; Pérez-González C ; Roca-Cusachs P Mol Biol Cell 2017[Jul]; 28 (14 ): 1847-1852 PMID28251923 show ga Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin ?5?1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the ?5?1-fn link is unknown. Here we show that the ?5?1/ZO-1 complex decreases the resistance to force of ?5?1-fn adhesions located at the edge of migrating cell monolayers while also increasing ?5?1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration. |Animals [MESH] |CHO Cells [MESH] |Cell Adhesion/physiology [MESH] |Cell Movement [MESH] |Cricetulus [MESH] |Extracellular Matrix/metabolism [MESH] |Fibronectins/metabolism/physiology [MESH] |Humans [MESH] |Integrin alpha5beta1/*metabolism/physiology [MESH] |Integrins/metabolism [MESH] |Mechanotransduction, Cellular/physiology [MESH] |Protein Binding [MESH]Binding of ZO-1 to ?5?1 integrins regulates the mechanical properties (epmc).pdf DeepDyve Pubget Overpricing