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10.1097/EDE.0000000000000684 http://scihub22266oqcxt.onion/10.1097/EDE.0000000000000684 C5540354!5540354 !28520643     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28520643 &cmd=llinks): Failed to open stream: HTTP request failed! 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Risk of Lung Cancer Mortality in Nuclear Workers from Internal Exposure to Alpha Particle-emitting Radionuclides |pdf=|usr=}}{{28520643 }} gab.com Text Risk of Lung Cancer Mortality in Nuclear Workers from Internal Exposure to Alpha Particle-emitting Radionuclides JO: Epidemiology http://www.kidney.de/pget.php?&tw=1&pmid=28520643 #FOAvip BACKGROUND: Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles-particularly through inhalation-occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers. METHODS: We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and plutonium workers. Cases were workers who died from lung cancer; one to three controls were matched to each. Lung doses from alpha-emitters were assessed using bioassay data. We estimated excess odds ratio (OR) of lung cancer per gray (Gy) of lung dose. RESULTS: The study comprised 553 cases and 1,333 controls. Median positive total alpha lung dose was 2.42 mGy (mean: 8.13 mGy; maximum: 316 mGy); for plutonium the median was 1.27 mGy and for uranium 2.17 mGy. Excess OR/Gy (90% confidence interval)-adjusted for external radiation, socioeconomic status, and smoking-was 11 (2.6, 24) for total alpha dose, 50 (17, 106) for plutonium, and 5.3 (-1.9, 18) for uranium. CONCLUSIONS: We found strong evidence for associations between low doses from alpha-emitters and lung cancer risk. The excess OR/Gy was greater for plutonium than uranium, though confidence intervals overlap. Risk estimates were similar to those estimated previously in plutonium workers, and in uranium miners exposed to radon and its progeny. Expressed as risk/equivalent dose in sieverts (Sv), our estimates are somewhat larger than but consistent with those for atomic bomb survivors.See video abstract at, http://links.lww.com/EDE/B232. Twit Text FOAVip Risk of Lung Cancer Mortality in Nuclear Workers from Internal Exposure to Alpha Particle-emitting Radionuclides ????Epidemiology http://www.kidney.de/pget.php?&tw=1&pmid=28520643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28520643 #FOAvip English Wikipedia <ref>{{Cite pmid|28520643 }}</ref> Risk of Lung Cancer Mortality in Nuclear Workers from Internal Exposure to Alpha Particle-emitting Radionuclides #MMPMID28520643 Grellier J ; Atkinson W ; Bérard P ; Bingham D ; Birchall A ; Blanchardon E ; Bull R ; Guseva Canu I ; Challeton-de Vathaire C ; Cockerill R ; Do MT ; Engels H ; Figuerola J ; Foster A ; Holmstock L ; Hurtgen C ; Laurier D ; Puncher M ; Riddell AE ; Samson E ; Thierry-Chef I ; Tirmarche M ; Vrijheid M ; Cardis E Epidemiology 2017[Sep]; 28 (5 ): 675-684 PMID28520643 show ga BACKGROUND: Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles-particularly through inhalation-occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers. METHODS: We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and plutonium workers. Cases were workers who died from lung cancer; one to three controls were matched to each. Lung doses from alpha-emitters were assessed using bioassay data. We estimated excess odds ratio (OR) of lung cancer per gray (Gy) of lung dose. RESULTS: The study comprised 553 cases and 1,333 controls. Median positive total alpha lung dose was 2.42 mGy (mean: 8.13 mGy; maximum: 316 mGy); for plutonium the median was 1.27 mGy and for uranium 2.17 mGy. Excess OR/Gy (90% confidence interval)-adjusted for external radiation, socioeconomic status, and smoking-was 11 (2.6, 24) for total alpha dose, 50 (17, 106) for plutonium, and 5.3 (-1.9, 18) for uranium. CONCLUSIONS: We found strong evidence for associations between low doses from alpha-emitters and lung cancer risk. The excess OR/Gy was greater for plutonium than uranium, though confidence intervals overlap. Risk estimates were similar to those estimated previously in plutonium workers, and in uranium miners exposed to radon and its progeny. Expressed as risk/equivalent dose in sieverts (Sv), our estimates are somewhat larger than but consistent with those for atomic bomb survivors.See video abstract at, http://links.lww.com/EDE/B232. |*Extraction and Processing Industry/statistics & numerical data [MESH] |Aged [MESH] |Alpha Particles/*adverse effects [MESH] |Belgium/epidemiology [MESH] |Case-Control Studies [MESH] |Female [MESH] |France/epidemiology [MESH] |Humans [MESH] |Lung Neoplasms/etiology/*mortality [MESH] |Male [MESH] |Middle Aged [MESH] |Occupational Exposure/*adverse effects/statistics & numerical data [MESH] |Plutonium/*adverse effects [MESH] |Radiometry [MESH] |Risk Factors [MESH] |United Kingdom/epidemiology [MESH]Risk of Lung Cancer Mortality in Nuclear Workers from Internal Exposur(epmc).pdf DeepDyve Pubget Overpricing