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10.4049/jimmunol.1700171 http://scihub22266oqcxt.onion/10.4049/jimmunol.1700171 C5539960!5539960 !28539431     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28539431 &cmd=llinks): Failed to open stream: HTTP request failed! 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Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota |pdf=|usr=}}{{28539431 }} gab.com Text Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539431 #FOAvip Th17 cells play a role as an inflammation mediator in a variety of autoimmune disorders, including inflammatory bowel disease, and thus are widely considered to be pathogenic. However, Th17 cells are present in the normal intestine and show a homeostatic phenotype; that is, they participate in the maintenance of intestinal homeostasis rather than inducing inflammation. We observed an enlarged Th17 population in the small intestine of C57BL/6.IgA(-/-) mice compared with wild-type mice, which was further amplified with cholera toxin (CT) immunization without causing intestinal inflammation. The increased Th17 induction and the correspondingly 10-fold higher CT B subunit-specific serum IgG response in IgA(-/-) mice after CT immunization was microbiota dependent and was associated with increased segmented filamentous bacteria in the small intestine of IgA(-/-) mice. Oral administration of vancomycin greatly dampened both CT immunogenicity and adjuvanticity, and the differential CT responses in IgA(-/-) and wild-type mice disappeared after intestinal microbiota equalization. Using gnotobiotic mouse models, we found that CT induction of homeostatic intestinal Th17 responses was supported not only by segmented filamentous bacteria, but also by other commensal bacteria. Furthermore, transcriptome analysis using IL-17A(hCD2) reporter mice revealed a similar gene expression profile in CT-induced intestinal Th17 cells and endogenous intestinal Th17 cells at homeostasis, with upregulated expression of a panel of immune-regulatory genes, which was distinctly different from the gene expression profile of pathogenic Th17 cells. Taken together, we identified a nonpathogenic signature of intestinal homeostatic Th17 cells, which are actively regulated by the commensal microbiota and can be selectively stimulated by CT. Twit Text FOAVip Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28539431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28539431 #FOAvip English Wikipedia <ref>{{Cite pmid|28539431 }}</ref> Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota #MMPMID28539431 Zhao Q ; Harbour SN ; Kolde R ; Latorre IJ ; Tun HM ; Schoeb TR ; Turner H ; Moon JJ ; Khafipour E ; Xavier RJ ; Weaver CT ; Elson CO J Immunol 2017[Jul]; 199 (1 ): 312-322 PMID28539431 show ga Th17 cells play a role as an inflammation mediator in a variety of autoimmune disorders, including inflammatory bowel disease, and thus are widely considered to be pathogenic. However, Th17 cells are present in the normal intestine and show a homeostatic phenotype; that is, they participate in the maintenance of intestinal homeostasis rather than inducing inflammation. We observed an enlarged Th17 population in the small intestine of C57BL/6.IgA(-/-) mice compared with wild-type mice, which was further amplified with cholera toxin (CT) immunization without causing intestinal inflammation. The increased Th17 induction and the correspondingly 10-fold higher CT B subunit-specific serum IgG response in IgA(-/-) mice after CT immunization was microbiota dependent and was associated with increased segmented filamentous bacteria in the small intestine of IgA(-/-) mice. Oral administration of vancomycin greatly dampened both CT immunogenicity and adjuvanticity, and the differential CT responses in IgA(-/-) and wild-type mice disappeared after intestinal microbiota equalization. Using gnotobiotic mouse models, we found that CT induction of homeostatic intestinal Th17 responses was supported not only by segmented filamentous bacteria, but also by other commensal bacteria. Furthermore, transcriptome analysis using IL-17A(hCD2) reporter mice revealed a similar gene expression profile in CT-induced intestinal Th17 cells and endogenous intestinal Th17 cells at homeostasis, with upregulated expression of a panel of immune-regulatory genes, which was distinctly different from the gene expression profile of pathogenic Th17 cells. Taken together, we identified a nonpathogenic signature of intestinal homeostatic Th17 cells, which are actively regulated by the commensal microbiota and can be selectively stimulated by CT. |*Homeostasis [MESH] |Animals [MESH] |Cholera Toxin/administration & dosage/*immunology [MESH] |Gastrointestinal Microbiome/*immunology/physiology [MESH] |Gene Expression Profiling [MESH] |Germ-Free Life [MESH] |IgA Deficiency/immunology [MESH] |Immunoglobulin A/immunology [MESH] |Inflammatory Bowel Diseases [MESH] |Intestinal Mucosa/*immunology/microbiology [MESH] |Intestine, Small/*immunology/microbiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Th17 Cells/*immunology [MESH]Selective Induction of Homeostatic Th17 Cells in the Murine Intestine (epmc).pdf DeepDyve Pubget Overpricing