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10.1038/ncb3525 http://scihub22266oqcxt.onion/10.1038/ncb3525 C5536221!5536221!28530659     free     free     free       Nat+Cell+Biol 2017 ; 19 (6): 689-97 Nephropedia Template TP {{tp|p=28530659|t=2017. Actin cortex architecture regulates cell surface tension |pdf=|usr=}}{{28530659}} gab.com Text Actin cortex architecture regulates cell surface tension JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28530659 #FOAvip Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell cycle progression. We then show that the actin filament length regulators CFL1, CAPZB, DIAPH1 regulate mitotic cortex thickness and find that both increasing and decreasing thickness decreases tension in mitosis. This suggests that the mitotic cortex is poised close to a tension maximum. Finally, using a computational model, we identify a physical mechanism by which maximum tension is achieved at intermediate actin filament lengths. Our results indicate that actin network architecture, alongside myosin activity, is key to cell surface tension regulation. Twit Text FOAVip Actin cortex architecture regulates cell surface tension ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28530659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28530659 #FOAvip English Wikipedia <ref>{{Cite pmid|28530659}}</ref> Actin cortex architecture regulates cell surface tension #MMPMID28530659 Chugh P; Clark AG; Smith MB; Cassani DAD; Dierkes K; Ragab A; Roux PP; Charras G; Salbreux G; Paluch EK Nat Cell Biol 2017[Jun]; 19 (6): 689-97 PMID28530659show ga Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell cycle progression. We then show that the actin filament length regulators CFL1, CAPZB, DIAPH1 regulate mitotic cortex thickness and find that both increasing and decreasing thickness decreases tension in mitosis. This suggests that the mitotic cortex is poised close to a tension maximum. Finally, using a computational model, we identify a physical mechanism by which maximum tension is achieved at intermediate actin filament lengths. Our results indicate that actin network architecture, alongside myosin activity, is key to cell surface tension regulation. äActin cortex architecture regulates cell surface tension (epmc).pdf DeepDyve Pubget Overpricing