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10.1021/acs.inorgchem.7b01114 http://scihub22266oqcxt.onion/10.1021/acs.inorgchem.7b01114 C5535315!5535315 !28631925     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28631925 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Inorg+Chem 2017 ; 56 (13 ): 7558-7565 Nephropedia Template TP {{tp|p=28631925 |t=2017. Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results |pdf=|usr=}}{{28631925 }} gab.com Text Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results JO: Inorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=28631925 #FOAvip We synthesized a series of polyoxometalate-bisphosphonate complexes containing Mo(VI)O(6) octahedra, zoledronate, or an N-alkyl (n-C(6) or n-C(8)) zoledronate analogue, and in two cases, Mn as a heterometal. Mo(6)L(2) (L = Zol, ZolC(6), ZolC(8)) and Mo(4)L(2)Mn (L = Zol, ZolC(8)) were characterized by using single-crystal X-ray crystallography and/or IR spectroscopy, elemental and energy dispersive X-ray analysis and (31)P NMR. We found promising activity against human nonsmall cell lung cancer (NCI-H460) cells with IC(50) values for growth inhibition of ?5 ?M per bisphosphonate ligand. The effects of bisphosphonate complexation on IC(50) decreased with increasing bisphosphonate chain length: C(0) ? 6.1×, C(6) ? 3.4×, and C(8) ? 1.1×. We then determined the activity of one of the most potent compounds in the series, Mo(4)Zol(2)Mn(III), against SK-ES-1 sarcoma cells in a mouse xenograft system finding a ?5× decrease in tumor volume than found with the parent compound zoledronate at the same compound dosing (5 ?g/mouse). Overall, the results are of interest since we show for the first time that heteropolyoxomolybdate-bisphosphonate hybrids kill tumor cells in vitro and significantly decrease tumor growth, in vivo, opening up new possibilities for targeting both Ras as well as epidermal growth factor receptor driven cancers. Twit Text FOAVip Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results ????Inorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=28631925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28631925 #FOAvip English Wikipedia <ref>{{Cite pmid|28631925 }}</ref> Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results #MMPMID28631925 Boulmier A ; Feng X ; Oms O ; Mialane P ; Rivière E ; Shin CJ ; Yao J ; Kubo T ; Furuta T ; Oldfield E ; Dolbecq A Inorg Chem 2017[Jul]; 56 (13 ): 7558-7565 PMID28631925 show ga We synthesized a series of polyoxometalate-bisphosphonate complexes containing Mo(VI)O(6) octahedra, zoledronate, or an N-alkyl (n-C(6) or n-C(8)) zoledronate analogue, and in two cases, Mn as a heterometal. Mo(6)L(2) (L = Zol, ZolC(6), ZolC(8)) and Mo(4)L(2)Mn (L = Zol, ZolC(8)) were characterized by using single-crystal X-ray crystallography and/or IR spectroscopy, elemental and energy dispersive X-ray analysis and (31)P NMR. We found promising activity against human nonsmall cell lung cancer (NCI-H460) cells with IC(50) values for growth inhibition of ?5 ?M per bisphosphonate ligand. The effects of bisphosphonate complexation on IC(50) decreased with increasing bisphosphonate chain length: C(0) ? 6.1×, C(6) ? 3.4×, and C(8) ? 1.1×. We then determined the activity of one of the most potent compounds in the series, Mo(4)Zol(2)Mn(III), against SK-ES-1 sarcoma cells in a mouse xenograft system finding a ?5× decrease in tumor volume than found with the parent compound zoledronate at the same compound dosing (5 ?g/mouse). Overall, the results are of interest since we show for the first time that heteropolyoxomolybdate-bisphosphonate hybrids kill tumor cells in vitro and significantly decrease tumor growth, in vivo, opening up new possibilities for targeting both Ras as well as epidermal growth factor receptor driven cancers. |Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Crystallography, X-Ray [MESH] |Diphosphonates/chemistry/*pharmacology [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Screening Assays, Antitumor [MESH] |Humans [MESH] |Models, Molecular [MESH] |Molecular Structure [MESH] |Organometallic Compounds/chemical synthesis/chemistry/*pharmacology [MESH] |Structure-Activity Relationship [MESH]Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synth(epmc).pdf DeepDyve Pubget Overpricing