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10.1016/j.devcel.2017.04.022 http://scihub22266oqcxt.onion/10.1016/j.devcel.2017.04.022 C5532731!5532731!28535371     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2017 ; 41 (4): 349-365.e3 Nephropedia Template TP {{tp|p=28535371|t=2017. Repression of interstitial identity in nephron progenitor cells by Pax2 establishes the nephron-interstitium boundary throughout kidney development |pdf=|usr=}}{{28535371}} gab.com Text Repression of interstitial identity in nephron progenitor cells by Pax2 establishes the nephron-interstitium boundary throughout kidney development JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535371 #FOAvip The kidney contains the functional units, the nephrons, surrounded by the renal interstitium. Previously, we discovered that, once Six2-expressing nephron progenitor cells and Foxd1-expressing renal interstitial progenitor cells form at the onset of kidney development, descendant cells from these populations contribute exclusively to the main body of nephrons and renal interstitial tissues, respectively, indicating a lineage boundary between the nephron and renal interstitial compartments. Currently, it is unclear how lineages are regulated during kidney organogenesis. We demonstrate that nephron progenitor cells lacking Pax2 fail to differentiate into nephron cells, but can switch fates into renal interstitium-like cell types. These data suggest that Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program. Thus, the lineage boundary between the nephron and renal interstitial compartments is maintained by the Pax2 activity in nephron progenitor cells during kidney organogenesis. Twit Text FOAVip Repression of interstitial identity in nephron progenitor cells by Pax2 establishes the nephron-interstitium boundary throughout kidney development ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28535371 #FOAvip English Wikipedia <ref>{{Cite pmid|28535371}}</ref> Repression of interstitial identity in nephron progenitor cells by Pax2 establishes the nephron-interstitium boundary throughout kidney development #MMPMID28535371 Naiman N; Fujioka K; Fujino M; Valerius MT; Potter SS; McMahon AP; Kobayashi A Dev Cell 2017[May]; 41 (4): 349-365.e3 PMID28535371show ga The kidney contains the functional units, the nephrons, surrounded by the renal interstitium. Previously, we discovered that, once Six2-expressing nephron progenitor cells and Foxd1-expressing renal interstitial progenitor cells form at the onset of kidney development, descendant cells from these populations contribute exclusively to the main body of nephrons and renal interstitial tissues, respectively, indicating a lineage boundary between the nephron and renal interstitial compartments. Currently, it is unclear how lineages are regulated during kidney organogenesis. We demonstrate that nephron progenitor cells lacking Pax2 fail to differentiate into nephron cells, but can switch fates into renal interstitium-like cell types. These data suggest that Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program. Thus, the lineage boundary between the nephron and renal interstitial compartments is maintained by the Pax2 activity in nephron progenitor cells during kidney organogenesis. äRepression of interstitial identity in nephron progenitor cells by Pax(epmc).pdf DeepDyve Pubget Overpricing