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2017 ; 41
(4
): 349-365.e3
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Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2
Establishes the Nephron-Interstitium Boundary during Kidney Development
#MMPMID28535371
Naiman N
; Fujioka K
; Fujino M
; Valerius MT
; Potter SS
; McMahon AP
; Kobayashi A
Dev Cell
2017[May]; 41
(4
): 349-365.e3
PMID28535371
show ga
The kidney contains the functional units, the nephrons, surrounded by the renal
interstitium. Previously we discovered that, once Six2-expressing nephron
progenitor cells and Foxd1-expressing renal interstitial progenitor cells form at
the onset of kidney development, descendant cells from these populations
contribute exclusively to the main body of nephrons and renal interstitial
tissues, respectively, indicating a lineage boundary between the nephron and
renal interstitial compartments. Currently it is unclear how lineages are
regulated during kidney organogenesis. We demonstrate that nephron progenitor
cells lacking Pax2 fail to differentiate into nephron cells but can switch fates
into renal interstitium-like cell types. These data suggest that Pax2
function maintains nephron progenitor cells by repressing a renal interstitial
cell program. Thus, the lineage boundary between the nephron and renal
interstitial compartments is maintained by the Pax2 activity in nephron
progenitor cells during kidney organogenesis.