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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell 2017 ; 169 (5): 780-91 Nephropedia Template TP
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Lamina-associated domains: links with chromosome architecture, heterochromatin and gene repression #MMPMID28525751
van Steensel B; Belmont AS
Cell 2017[May]; 169 (5): 780-91 PMID28525751show ga
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.