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10.1016/j.cell.2017.04.022

http://scihub22266oqcxt.onion/10.1016/j.cell.2017.04.022
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C5532494!5532494!28525751
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suck abstract from ncbi


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pmid28525751      Cell 2017 ; 169 (5): 780-91
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  • Lamina-associated domains: links with chromosome architecture, heterochromatin and gene repression #MMPMID28525751
  • van Steensel B; Belmont AS
  • Cell 2017[May]; 169 (5): 780-91 PMID28525751show ga
  • In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.
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