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10.1172/JCI93450 http://scihub22266oqcxt.onion/10.1172/JCI93450 C5531397!5531397 !28650341     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28650341 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2017 ; 127 (8 ): 2946-2956 Nephropedia Template TP {{tp|p=28650341 |t=2017. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints |pdf=|usr=}}{{28650341 }} gab.com Text Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28650341 #FOAvip In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints. Here, we used discovery-based proteomics to detect HLA-DR-presented peptides in synovia or peripheral blood mononuclear cells and identified 2 autoantigens, N-acetylglucosamine-6-sulfatase (GNS) and filamin A (FLNA), as targets of T and B cell responses in 52% and 56% of RA patients, respectively. Both GNS and FLNA were highly expressed in synovia. GNS appeared to be citrullinated, and GNS antibody values correlated with anti-citrullinated protein antibody (ACPA) levels. FLNA did not show the same results. The HLA-DR-presented GNS peptide has marked sequence homology with epitopes from sulfatase proteins of the Prevotella sp. and Parabacteroides sp., whereas the HLA-DR-presented FLNA peptide has homology with epitopes from proteins of the Prevotella sp. and Butyricimonas sp., another gut commensal. Patients with T cell reactivity with each self-peptide also had responses to the corresponding microbial peptides, and the levels were directly correlated. Furthermore, HLA-DR molecules encoded by shared-epitope (SE) alleles were predicted to bind these self- and microbial peptides strongly, and these responses were more common in RA patients with SE alleles. Thus, sequence homology between T cell epitopes of 2 self-proteins and a related order of gut microbes may provide a link between mucosal and joint immunity in patients with RA. Twit Text FOAVip Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28650341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28650341 #FOAvip English Wikipedia <ref>{{Cite pmid|28650341 }}</ref> Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints #MMPMID28650341 Pianta A ; Arvikar SL ; Strle K ; Drouin EE ; Wang Q ; Costello CE ; Steere AC J Clin Invest 2017[Aug]; 127 (8 ): 2946-2956 PMID28650341 show ga In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints. Here, we used discovery-based proteomics to detect HLA-DR-presented peptides in synovia or peripheral blood mononuclear cells and identified 2 autoantigens, N-acetylglucosamine-6-sulfatase (GNS) and filamin A (FLNA), as targets of T and B cell responses in 52% and 56% of RA patients, respectively. Both GNS and FLNA were highly expressed in synovia. GNS appeared to be citrullinated, and GNS antibody values correlated with anti-citrullinated protein antibody (ACPA) levels. FLNA did not show the same results. The HLA-DR-presented GNS peptide has marked sequence homology with epitopes from sulfatase proteins of the Prevotella sp. and Parabacteroides sp., whereas the HLA-DR-presented FLNA peptide has homology with epitopes from proteins of the Prevotella sp. and Butyricimonas sp., another gut commensal. Patients with T cell reactivity with each self-peptide also had responses to the corresponding microbial peptides, and the levels were directly correlated. Furthermore, HLA-DR molecules encoded by shared-epitope (SE) alleles were predicted to bind these self- and microbial peptides strongly, and these responses were more common in RA patients with SE alleles. Thus, sequence homology between T cell epitopes of 2 self-proteins and a related order of gut microbes may provide a link between mucosal and joint immunity in patients with RA. |*Gastrointestinal Microbiome [MESH] |Antirheumatic Agents/therapeutic use [MESH] |Arthritis, Rheumatoid/drug therapy/*immunology [MESH] |Autoantigens/*immunology [MESH] |Autoimmunity/*immunology [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Epitopes/immunology [MESH] |Filamins/immunology [MESH] |HLA-DR Antigens/immunology [MESH] |Humans [MESH] |Immunoglobulin A/immunology [MESH] |Immunoglobulin G/immunology [MESH] |Joints/*immunology/pathology [MESH] |Leukocytes, Mononuclear/cytology/*immunology/metabolism [MESH] |Sulfatases/immunology [MESH]Two rheumatoid arthritis-specific autoantigens correlate microbial imm(epmc).pdf DeepDyve Pubget Overpricing