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10.3322/caac.21398 http://scihub22266oqcxt.onion/10.3322/caac.21398 C5530583!5530583!28481406     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       CA+Cancer+J+Clin 2017 ; 67 (4): 326-44 Nephropedia Template TP {{tp|p=28481406|t=2017. The Role of the Microbiome in Cancer Development and Therapy |pdf=|usr=}}{{28481406}} gab.com Text The Role of the Microbiome in Cancer Development and Therapy JO: CA Cancer J Clin http://www.kidney.de/pget.php?&tw=1&pmid=28481406 #FOAvip The human body harbors an enormous number of microbiota that influence cancer susceptibility, in part, via their prodigious metabolic capacity and their profound influence on immune cell function. Microbial pathogens drive tumorigenesis in 15?20% of cancer cases. An even larger number of malignancies are associated with an altered composition of commensal microbiota (dysbiosis) based on microbiome studies utilizing metagenomic sequencing. Although association studies cannot distinguish whether changes in microbiota are causes or effects of cancer, a causative role is supported by rigorously controlled pre-clinical studies utilizing gnotobiotic mouse models colonized with one or more specific bacteria. These studies demonstrate that microbiota can alter cancer susceptibility and progression by diverse mechanisms such as modulating inflammation, inducing DNA damage, and producing metabolites involved in oncogenesis or tumor suppression. Evidence is emerging that microbiota can be manipulated for improving cancer treatment. By incorporating probiotics as adjuvants for checkpoint immunotherapy or by designing small molecules that target microbial enzymes, microbiota can be harnessed to improve cancer care. Twit Text FOAVip The Role of the Microbiome in Cancer Development and Therapy ????CA Cancer J Clin http://www.kidney.de/pget.php?&tw=1&pmid=28481406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28481406 #FOAvip English Wikipedia <ref>{{Cite pmid|28481406}}</ref> The Role of the Microbiome in Cancer Development and Therapy #MMPMID28481406 Bhatt AP; Redinbo MR; Bultman SJ CA Cancer J Clin 2017[Jul]; 67 (4): 326-44 PMID28481406show ga The human body harbors an enormous number of microbiota that influence cancer susceptibility, in part, via their prodigious metabolic capacity and their profound influence on immune cell function. Microbial pathogens drive tumorigenesis in 15?20% of cancer cases. An even larger number of malignancies are associated with an altered composition of commensal microbiota (dysbiosis) based on microbiome studies utilizing metagenomic sequencing. Although association studies cannot distinguish whether changes in microbiota are causes or effects of cancer, a causative role is supported by rigorously controlled pre-clinical studies utilizing gnotobiotic mouse models colonized with one or more specific bacteria. These studies demonstrate that microbiota can alter cancer susceptibility and progression by diverse mechanisms such as modulating inflammation, inducing DNA damage, and producing metabolites involved in oncogenesis or tumor suppression. Evidence is emerging that microbiota can be manipulated for improving cancer treatment. By incorporating probiotics as adjuvants for checkpoint immunotherapy or by designing small molecules that target microbial enzymes, microbiota can be harnessed to improve cancer care. äThe Role of the Microbiome in Cancer Development and Therapy (epmc).pdf DeepDyve Pubget Overpricing