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10.1136/annrheumdis-2016-210448 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2016-210448 C5530351!5530351 !27965259     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27965259 &cmd=llinks): Failed to open stream: HTTP request failed! 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Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren s syndrome |pdf=|usr=}}{{27965259 }} gab.com Text Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren s syndrome JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=27965259 #FOAvip Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and histological interpretation is variable and needs to be standardised for use in clinical trials. A modified European League Against Rheumatism consensus guideline development strategy was used. The steering committee of the ad hoc working group identified key outstanding points of variability in LSG acquisition and analysis. A 2-day workshop was held to develop consensus where possible and identify points where further discussion/data was needed. These points were reviewed by a subgroup of experts on PSS histopathology and then circulated via an online survey to 50 stakeholder experts consisting of rheumatologists, histopathologists and oral medicine specialists, to assess level of agreement (0-10 scale) and comments. Criteria for agreement were a mean score ?6/10 and 75% of respondents scoring ?6/10. Thirty-nine (78%) experts responded and 16 points met criteria for agreement. These points are focused on tissue requirements, identification of the characteristic focal lymphocytic sialadenitis, calculation of the focus score, identification of germinal centres, assessment of the area of leucocyte infiltration, reporting standards and use of prestudy samples for clinical trials. We provide standardised consensus guidance for the use of labial salivary gland histopathology in the classification of PSS and in clinical trials and identify areas where further research is required to achieve evidence-based consensus. Twit Text FOAVip Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren s syndrome ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=27965259 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27965259 #FOAvip English Wikipedia <ref>{{Cite pmid|27965259 }}</ref> Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren s syndrome #MMPMID27965259 Fisher BA ; Jonsson R ; Daniels T ; Bombardieri M ; Brown RM ; Morgan P ; Bombardieri S ; Ng WF ; Tzioufas AG ; Vitali C ; Shirlaw P ; Haacke E ; Costa S ; Bootsma H ; Devauchelle-Pensec V ; Radstake TR ; Mariette X ; Richards A ; Stack R ; Bowman SJ ; Barone F Ann Rheum Dis 2017[Jul]; 76 (7 ): 1161-1168 PMID27965259 show ga Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and histological interpretation is variable and needs to be standardised for use in clinical trials. A modified European League Against Rheumatism consensus guideline development strategy was used. The steering committee of the ad hoc working group identified key outstanding points of variability in LSG acquisition and analysis. A 2-day workshop was held to develop consensus where possible and identify points where further discussion/data was needed. These points were reviewed by a subgroup of experts on PSS histopathology and then circulated via an online survey to 50 stakeholder experts consisting of rheumatologists, histopathologists and oral medicine specialists, to assess level of agreement (0-10 scale) and comments. Criteria for agreement were a mean score ?6/10 and 75% of respondents scoring ?6/10. Thirty-nine (78%) experts responded and 16 points met criteria for agreement. These points are focused on tissue requirements, identification of the characteristic focal lymphocytic sialadenitis, calculation of the focus score, identification of germinal centres, assessment of the area of leucocyte infiltration, reporting standards and use of prestudy samples for clinical trials. We provide standardised consensus guidance for the use of labial salivary gland histopathology in the classification of PSS and in clinical trials and identify areas where further research is required to achieve evidence-based consensus. |Biopsy [MESH] |Delphi Technique [MESH] |Germinal Center/*pathology [MESH] |Humans [MESH] |Leukocytes/pathology [MESH] |Lip [MESH] |Lymphocytes/*pathology [MESH] |Reference Standards [MESH] |Salivary Glands, Minor/*pathology [MESH] |Sialadenitis/*pathology [MESH]Standardisation of labial salivary gland histopathology in clinical tr(epmc).pdf DeepDyve Pubget Overpricing