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10.1136/annrheumdis-2016-209991 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2016-209991 C5530344!5530344 !28043998     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28043998 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Rheum+Dis 2017 ; 76 (7 ): 1184-1190 Nephropedia Template TP {{tp|p=28043998 |t=2017. Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands |pdf=|usr=}}{{28043998 }} gab.com Text Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=28043998 #FOAvip OBJECTIVES: To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population. METHODS: Lifelines is a multidisciplinary prospective population-based cohort study in the Netherlands. Cross-sectional data from 40?136 participants were used. The detection of ACPA was performed by measuring anti-CCP2 on the Phadia-250 analyser with levels ?6.2?U/mL considered positive. An extensive questionnaire was taken on demographic and clinical information, including smoking, periodontal health and early symptoms of musculoskeletal disorders. RA was defined by a combination of self-reported RA, medication use for the indication of rheumatism and visiting a medical specialist within the last year. RESULTS: Of the total 40?136 unselected individuals, 401 (1.0%) had ACPA level ?6.2?U/mL. ACPA positivity was significantly associated with older age, female gender, smoking, joint complaints, RA and first degree relatives with rheumatism. Of the ACPA-positive participants, 22.4% had RA (15.2% had defined RA according to our criteria and 7.2% self-reported RA only). In participants without RA, 311 (0.8%) were ACPA-positive. In the non-RA group, older age, smoking and joint complaints remained significantly more frequently present in ACPA-positive compared with ACPA-negative participants. CONCLUSIONS: In this large population-based study, the prevalence of ACPA levels ?6.2?U/mL was 1.0% for the total group and 0.8% when excluding patients with RA. Older age, smoking and joint complaints were more frequently present in ACPA-positive Lifelines participants. To our knowledge, this study is the largest study to date on ACPA positivity in the general, mostly Caucasian population. Twit Text FOAVip Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=28043998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28043998 #FOAvip English Wikipedia <ref>{{Cite pmid|28043998 }}</ref> Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands #MMPMID28043998 van Zanten A ; Arends S ; Roozendaal C ; Limburg PC ; Maas F ; Trouw LA ; Toes REM ; Huizinga TWJ ; Bootsma H ; Brouwer E Ann Rheum Dis 2017[Jul]; 76 (7 ): 1184-1190 PMID28043998 show ga OBJECTIVES: To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population. METHODS: Lifelines is a multidisciplinary prospective population-based cohort study in the Netherlands. Cross-sectional data from 40?136 participants were used. The detection of ACPA was performed by measuring anti-CCP2 on the Phadia-250 analyser with levels ?6.2?U/mL considered positive. An extensive questionnaire was taken on demographic and clinical information, including smoking, periodontal health and early symptoms of musculoskeletal disorders. RA was defined by a combination of self-reported RA, medication use for the indication of rheumatism and visiting a medical specialist within the last year. RESULTS: Of the total 40?136 unselected individuals, 401 (1.0%) had ACPA level ?6.2?U/mL. ACPA positivity was significantly associated with older age, female gender, smoking, joint complaints, RA and first degree relatives with rheumatism. Of the ACPA-positive participants, 22.4% had RA (15.2% had defined RA according to our criteria and 7.2% self-reported RA only). In participants without RA, 311 (0.8%) were ACPA-positive. In the non-RA group, older age, smoking and joint complaints remained significantly more frequently present in ACPA-positive compared with ACPA-negative participants. CONCLUSIONS: In this large population-based study, the prevalence of ACPA levels ?6.2?U/mL was 1.0% for the total group and 0.8% when excluding patients with RA. Older age, smoking and joint complaints were more frequently present in ACPA-positive Lifelines participants. To our knowledge, this study is the largest study to date on ACPA positivity in the general, mostly Caucasian population. |Adolescent [MESH] |Adult [MESH] |Age Factors [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Alcohol Drinking/epidemiology [MESH] |Arthralgia/epidemiology/*immunology [MESH] |Arthritis, Rheumatoid/epidemiology/genetics/*immunology [MESH] |Autoantibodies/*immunology [MESH] |Body Mass Index [MESH] |Cross-Sectional Studies [MESH] |Female [MESH] |Humans [MESH] |Logistic Models [MESH] |Male [MESH] |Menarche [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Netherlands [MESH] |Parity [MESH] |Peptides, Cyclic/*immunology [MESH] |Periodontitis/epidemiology [MESH] |Prospective Studies [MESH] |Risk Factors [MESH] |Sex Factors [MESH] |Smoking/epidemiology [MESH]Presence of anticitrullinated protein antibodies in a large population(epmc).pdf DeepDyve Pubget Overpricing