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10.1158/1078-0432.CCR-16-3122 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-16-3122 C5529121!5529121!28341752     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Cancer+Res 2017 ; 23 (13): 3241-50 Nephropedia Template TP {{tp|p=28341752|t=2017. The Promise of Targeting Macrophages in Cancer Therapy |pdf=|usr=}}{{28341752}} gab.com Text The Promise of Targeting Macrophages in Cancer Therapy JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28341752 #FOAvip Cancer therapy has developed around the concept of killing, or stopping the growth of, the cancer cells. Molecularly targeted therapy is the modern expression of this paradigm. Increasingly, however, the realization that the cancer has co-opted the normal cells of the stroma for its own survival has led to the concept that the tumor microenvironment (TME) could be targeted for effective therapy. In this Review we outline the importance of tumor associated macrophages (TAMs), a major component of the TME, in the response of tumors to cancer therapy. We discuss the normal role of macrophages in wound healing, the major phenotypes of TAMs and their role in blunting the efficacy to cancer treatment by radiation and anticancer drugs both by promoting tumor angiogenesis and by suppressing antitumor immunity. Finally we review the many preclinical studies that have shown that the response of tumors to irradiation and anticancer drugs can be improved, sometimes markedly so, by depleting TAMs from tumors or by suppressing their polarization from an M1 to an M2 phenotype. The data clearly support the validity of clinical testing of combining targeting TAMs with conventional therapy. Twit Text FOAVip The Promise of Targeting Macrophages in Cancer Therapy ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28341752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28341752 #FOAvip English Wikipedia <ref>{{Cite pmid|28341752}}</ref> The Promise of Targeting Macrophages in Cancer Therapy #MMPMID28341752 Brown JM; Recht L; Strober S Clin Cancer Res 2017[Jul]; 23 (13): 3241-50 PMID28341752show ga Cancer therapy has developed around the concept of killing, or stopping the growth of, the cancer cells. Molecularly targeted therapy is the modern expression of this paradigm. Increasingly, however, the realization that the cancer has co-opted the normal cells of the stroma for its own survival has led to the concept that the tumor microenvironment (TME) could be targeted for effective therapy. In this Review we outline the importance of tumor associated macrophages (TAMs), a major component of the TME, in the response of tumors to cancer therapy. We discuss the normal role of macrophages in wound healing, the major phenotypes of TAMs and their role in blunting the efficacy to cancer treatment by radiation and anticancer drugs both by promoting tumor angiogenesis and by suppressing antitumor immunity. Finally we review the many preclinical studies that have shown that the response of tumors to irradiation and anticancer drugs can be improved, sometimes markedly so, by depleting TAMs from tumors or by suppressing their polarization from an M1 to an M2 phenotype. The data clearly support the validity of clinical testing of combining targeting TAMs with conventional therapy. äThe Promise of Targeting Macrophages in Cancer Therapy (epmc).pdf DeepDyve Pubget Overpricing