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10.1080/15548627.2017.1299314 http://scihub22266oqcxt.onion/10.1080/15548627.2017.1299314 C5529078!5529078!28324658     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2017 ; 13 (7): 1256-7 Nephropedia Template TP {{tp|p=28324658|t=2017. Mitochondrial respiration links TOR complex 2 signaling to calcium regulation and autophagy |pdf=|usr=}}{{28324658}} gab.com Text Mitochondrial respiration links TOR complex 2 signaling to calcium regulation and autophagy JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28324658 #FOAvip The target of rapamycin (TOR) kinase is a conserved regulator of cell growth and functions within 2 different protein complexes, TORC1 and TORC2, where TORC2 positively controls macroautophagy/autophagy during amino acid starvation. Under these conditions, TORC2 signaling inhibits the activity of the calcium-regulated phosphatase calcineurin and promotes the general amino acid control (GAAC) response and autophagy. Here we demonstrate that TORC2 regulates calcineurin by controlling the respiratory activity of mitochondria. In particular, we find that mitochondrial oxidative stress affects the calcium channel regulatory protein Mid1, which we show is an essential upstream activator of calcineurin. Thus, these findings describe a novel regulation for autophagy that involves TORC2 signaling, mitochondrial respiration, and calcium homeostasis. Twit Text FOAVip Mitochondrial respiration links TOR complex 2 signaling to calcium regulation and autophagy ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28324658 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28324658 #FOAvip English Wikipedia <ref>{{Cite pmid|28324658}}</ref> Mitochondrial respiration links TOR complex 2 signaling to calcium regulation and autophagy #MMPMID28324658 Vlahakis A; Lopez Muniozguren N; Powers T Autophagy 2017[]; 13 (7): 1256-7 PMID28324658show ga The target of rapamycin (TOR) kinase is a conserved regulator of cell growth and functions within 2 different protein complexes, TORC1 and TORC2, where TORC2 positively controls macroautophagy/autophagy during amino acid starvation. Under these conditions, TORC2 signaling inhibits the activity of the calcium-regulated phosphatase calcineurin and promotes the general amino acid control (GAAC) response and autophagy. Here we demonstrate that TORC2 regulates calcineurin by controlling the respiratory activity of mitochondria. In particular, we find that mitochondrial oxidative stress affects the calcium channel regulatory protein Mid1, which we show is an essential upstream activator of calcineurin. Thus, these findings describe a novel regulation for autophagy that involves TORC2 signaling, mitochondrial respiration, and calcium homeostasis. äMitochondrial respiration links TOR complex 2 signaling to calcium reg(epmc).pdf DeepDyve Pubget Overpricing