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10.1016/j.chembiol.2017.05.023 http://scihub22266oqcxt.onion/10.1016/j.chembiol.2017.05.023 C5528179!5528179!28648380     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Chem+Biol 2017 ; 24 (7): 787-800 Nephropedia Template TP {{tp|p=28648380|t=2017. Privileged electrophile sensors: a resource for covalent drug development |pdf=|usr=}}{{28648380}} gab.com Text Privileged electrophile sensors: a resource for covalent drug development JO: Cell Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28648380 #FOAvip This Perspective delineates how redox signaling impacts activity of specific enzyme isoforms and how this property may be harnessed for rational drug design. Covalent drugs have resurged in recent years and several reports have extolled the general virtues of developing irreversible inhibitors. Indeed, many modern pharmaceuticals contain electrophilic appendages. Several invoke a warhead that hijacks active-site nucleophiles whereas others take advantage of spectator nucleophilic side-chains that do not participate in enzymatic chemistry, but are poised to bind/react with electrophiles. The latest data suggest that innate electrophile sensing?that enables rapid reaction with an endogenous signaling electrophile?is a quintessential resource for development of covalent drugs. For instance, based on recent work documenting isoform-specific electrophile sensing, isozyme non-specific drugs may be converted to isozyme-specific analogs by hijacking privileged first-responder electrophile-sensing cysteines. Because this approach targets functionally-relevant cysteines, we can simultaneously harness previously-untapped moonlighting roles of enzymes linked to redox sensing. Twit Text FOAVip Privileged electrophile sensors: a resource for covalent drug development ????Cell Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28648380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28648380 #FOAvip English Wikipedia <ref>{{Cite pmid|28648380}}</ref> Privileged electrophile sensors: a resource for covalent drug development #MMPMID28648380 Long MJC; Aye Y Cell Chem Biol 2017[Jul]; 24 (7): 787-800 PMID28648380show ga This Perspective delineates how redox signaling impacts activity of specific enzyme isoforms and how this property may be harnessed for rational drug design. Covalent drugs have resurged in recent years and several reports have extolled the general virtues of developing irreversible inhibitors. Indeed, many modern pharmaceuticals contain electrophilic appendages. Several invoke a warhead that hijacks active-site nucleophiles whereas others take advantage of spectator nucleophilic side-chains that do not participate in enzymatic chemistry, but are poised to bind/react with electrophiles. The latest data suggest that innate electrophile sensing?that enables rapid reaction with an endogenous signaling electrophile?is a quintessential resource for development of covalent drugs. For instance, based on recent work documenting isoform-specific electrophile sensing, isozyme non-specific drugs may be converted to isozyme-specific analogs by hijacking privileged first-responder electrophile-sensing cysteines. Because this approach targets functionally-relevant cysteines, we can simultaneously harness previously-untapped moonlighting roles of enzymes linked to redox sensing. äPrivileged electrophile sensors: a resource for covalent drug developm(epmc).pdf DeepDyve Pubget Overpricing