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10.4049/jimmunol.1601959 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601959 C5528153!5528153!28600291     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 199 (2): 677-87 Nephropedia Template TP {{tp|p=28600291|t=2017. Sphingosine 1-phosphate lyase enhances the activation of IKK? to promote type I interferon-mediated innate immune response to influenza A virus infection |pdf=|usr=}}{{28600291}} gab.com Text Sphingosine 1-phosphate lyase enhances the activation of IKK to promote type I interferon-mediated innate immune response to influenza A virus infection JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28600291 #FOAvip Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid, S1P. We have previously reported that overexpressed SPL displays anti-influenza viral activity; however the underlying mechanism is incompletely understood. In this study, we demonstrate that SPL functions as a positive regulator of IKK? to propel type I interferon (IFN)-mediated innate immune response against viral infection. Exogenous SPL expression inhibited influenza A virus (IAV) replication, which correlated with an increase in type I IFN production and interferon stimulated gene accumulation upon infection. In contrast, the lack of SPL expression led to an elevated cellular susceptibility to IAV infection. In support of this, SPL-deficient cells were defective in mounting an effective IFN response when stimulated by influenza viral RNAs. SPL augmented the activation status of IKK?, and enhanced the kinase-induced phosphorylation of IRF3 and synthesis of type I IFNs. However, S1P degradation-incompetent form of SPL also enhanced IFN responses, suggesting that SPL?s pro-IFN function is independent of S1P. Biochemical analysis revealed that SPL as well as the mutant form of SPL interact with IKK?. Importantly, when endogenous IKK? was down-regulated by an siRNA approach, SPL?s anti-influenza viral activity was markedly suppressed. This indicates that IKK? is crucial for SPL-mediated inhibition of influenza virus replication. Thus, the results illustrate the functional significance of the SPL-IKK?-IFN axis during host innate immunity against viral infection. Twit Text FOAVip Sphingosine 1-phosphate lyase enhances the activation of IKK to promote type I interferon-mediated innate immune response to influenza A virus infection ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28600291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28600291 #FOAvip English Wikipedia <ref>{{Cite pmid|28600291}}</ref> Sphingosine 1-phosphate lyase enhances the activation of IKK? to promote type I interferon-mediated innate immune response to influenza A virus infection #MMPMID28600291 Vijayan M; Xia C; Song YE; Ngo H; Studstill CJ; Drews K; Fox TE; Johnson MC; Hiscott J; Kester M; Alexander S; Hahm B J Immunol 2017[Jul]; 199 (2): 677-87 PMID28600291show ga Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid, S1P. We have previously reported that overexpressed SPL displays anti-influenza viral activity; however the underlying mechanism is incompletely understood. In this study, we demonstrate that SPL functions as a positive regulator of IKK? to propel type I interferon (IFN)-mediated innate immune response against viral infection. Exogenous SPL expression inhibited influenza A virus (IAV) replication, which correlated with an increase in type I IFN production and interferon stimulated gene accumulation upon infection. In contrast, the lack of SPL expression led to an elevated cellular susceptibility to IAV infection. In support of this, SPL-deficient cells were defective in mounting an effective IFN response when stimulated by influenza viral RNAs. SPL augmented the activation status of IKK?, and enhanced the kinase-induced phosphorylation of IRF3 and synthesis of type I IFNs. However, S1P degradation-incompetent form of SPL also enhanced IFN responses, suggesting that SPL?s pro-IFN function is independent of S1P. Biochemical analysis revealed that SPL as well as the mutant form of SPL interact with IKK?. Importantly, when endogenous IKK? was down-regulated by an siRNA approach, SPL?s anti-influenza viral activity was markedly suppressed. This indicates that IKK? is crucial for SPL-mediated inhibition of influenza virus replication. Thus, the results illustrate the functional significance of the SPL-IKK?-IFN axis during host innate immunity against viral infection. äSphingosine 1-phosphate lyase enhances the activation of IKK? to promo(epmc).pdf DeepDyve Pubget Overpricing