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10.4049/jimmunol.1601959 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601959 C5528153!5528153 !28600291     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28600291 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 199 (2 ): 677-687 Nephropedia Template TP {{tp|p=28600291 |t=2017. Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection |pdf=|usr=}}{{28600291 }} gab.com Text Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28600291 #FOAvip Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid S1P. We have previously reported that overexpressed SPL displays anti-influenza viral activity; however, the underlying mechanism is incompletely understood. In this study, we demonstrate that SPL functions as a positive regulator of IKK? to propel type I IFN-mediated innate immune responses against viral infection. Exogenous SPL expression inhibited influenza A virus replication, which correlated with an increase in type I IFN production and IFN-stimulated gene accumulation upon infection. In contrast, the lack of SPL expression led to an elevated cellular susceptibility to influenza A virus infection. In support of this, SPL-deficient cells were defective in mounting an effective IFN response when stimulated by influenza viral RNAs. SPL augmented the activation status of IKK? and enhanced the kinase-induced phosphorylation of IRF3 and the synthesis of type I IFNs. However, the S1P degradation-incompetent form of SPL also enhanced IFN responses, suggesting that SPL's pro-IFN function is independent of S1P. Biochemical analyses revealed that SPL, as well as the mutant form of SPL, interacts with IKK?. Importantly, when endogenous IKK? was downregulated using a small interfering RNA approach, SPL's anti-influenza viral activity was markedly suppressed. This indicates that IKK? is crucial for SPL-mediated inhibition of influenza virus replication. Thus, the results illustrate the functional significance of the SPL-IKK?-IFN axis during host innate immunity against viral infection. Twit Text FOAVip Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28600291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28600291 #FOAvip English Wikipedia <ref>{{Cite pmid|28600291 }}</ref> Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection #MMPMID28600291 Vijayan M ; Xia C ; Song YE ; Ngo H ; Studstill CJ ; Drews K ; Fox TE ; Johnson MC ; Hiscott J ; Kester M ; Alexander S ; Hahm B J Immunol 2017[Jul]; 199 (2 ): 677-687 PMID28600291 show ga Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid S1P. We have previously reported that overexpressed SPL displays anti-influenza viral activity; however, the underlying mechanism is incompletely understood. In this study, we demonstrate that SPL functions as a positive regulator of IKK? to propel type I IFN-mediated innate immune responses against viral infection. Exogenous SPL expression inhibited influenza A virus replication, which correlated with an increase in type I IFN production and IFN-stimulated gene accumulation upon infection. In contrast, the lack of SPL expression led to an elevated cellular susceptibility to influenza A virus infection. In support of this, SPL-deficient cells were defective in mounting an effective IFN response when stimulated by influenza viral RNAs. SPL augmented the activation status of IKK? and enhanced the kinase-induced phosphorylation of IRF3 and the synthesis of type I IFNs. However, the S1P degradation-incompetent form of SPL also enhanced IFN responses, suggesting that SPL's pro-IFN function is independent of S1P. Biochemical analyses revealed that SPL, as well as the mutant form of SPL, interacts with IKK?. Importantly, when endogenous IKK? was downregulated using a small interfering RNA approach, SPL's anti-influenza viral activity was markedly suppressed. This indicates that IKK? is crucial for SPL-mediated inhibition of influenza virus replication. Thus, the results illustrate the functional significance of the SPL-IKK?-IFN axis during host innate immunity against viral infection. |*Immunity, Innate [MESH] |A549 Cells [MESH] |Aldehyde-Lyases/deficiency/genetics/*metabolism [MESH] |Down-Regulation [MESH] |Enzyme Activation [MESH] |HEK293 Cells [MESH] |Humans [MESH] |I-kappa B Kinase/genetics/*metabolism [MESH] |Influenza A virus/*immunology/physiology [MESH] |Interferon Regulatory Factor-3/metabolism [MESH] |Interferon Type I/biosynthesis/*immunology [MESH] |Lysophospholipids/metabolism [MESH] |Phosphorylation [MESH] |Sphingosine/analogs & derivatives/metabolism [MESH]Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promo(epmc).pdf DeepDyve Pubget Overpricing