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10.1038/ncomms16034 http://scihub22266oqcxt.onion/10.1038/ncomms16034 C5527284!5527284 !28737171     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28737171 &cmd=llinks): Failed to open stream: HTTP request failed! 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BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease |pdf=|usr=}}{{28737171 }} gab.com Text BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28737171 #FOAvip Epicardium-derived cells (EPDCs) contribute cardiovascular cell types during development and in adulthood respond to Thymosin ?4 (T?4) and myocardial infarction (MI) by reactivating a fetal gene programme to promote neovascularization and cardiomyogenesis. The mechanism for epicardial gene (re-)activation remains elusive. Here we reveal that BRG1, the essential ATPase subunit of the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms' tumour 1 (Wt1), fetal EPDC activation and subsequent differentiation into coronary smooth muscle, and restores Wt1 activity upon MI. BRG1 physically interacts with T?4 and is recruited by CCAAT/enhancer-binding protein ? (C/EBP?) to discrete regulatory elements in the Wt1 locus. BRG1-T?4 co-operative binding promotes optimal transcription of Wt1 as the master regulator of embryonic EPDCs. Moreover, chromatin immunoprecipitation-sequencing reveals BRG1 binding at further key loci suggesting SWI/SNF activity across the fetal epicardial gene programme. These findings reveal essential functions for chromatin-remodelling in the activation of EPDCs during cardiovascular development and repair. Twit Text FOAVip BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28737171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28737171 #FOAvip English Wikipedia <ref>{{Cite pmid|28737171 }}</ref> BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease #MMPMID28737171 Vieira JM ; Howard S ; Villa Del Campo C ; Bollini S ; Dubé KN ; Masters M ; Barnette DN ; Rohling M ; Sun X ; Hankins LE ; Gavriouchkina D ; Williams R ; Metzger D ; Chambon P ; Sauka-Spengler T ; Davies B ; Riley PR Nat Commun 2017[Jul]; 8 (ä): 16034 PMID28737171 show ga Epicardium-derived cells (EPDCs) contribute cardiovascular cell types during development and in adulthood respond to Thymosin ?4 (T?4) and myocardial infarction (MI) by reactivating a fetal gene programme to promote neovascularization and cardiomyogenesis. The mechanism for epicardial gene (re-)activation remains elusive. Here we reveal that BRG1, the essential ATPase subunit of the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms' tumour 1 (Wt1), fetal EPDC activation and subsequent differentiation into coronary smooth muscle, and restores Wt1 activity upon MI. BRG1 physically interacts with T?4 and is recruited by CCAAT/enhancer-binding protein ? (C/EBP?) to discrete regulatory elements in the Wt1 locus. BRG1-T?4 co-operative binding promotes optimal transcription of Wt1 as the master regulator of embryonic EPDCs. Moreover, chromatin immunoprecipitation-sequencing reveals BRG1 binding at further key loci suggesting SWI/SNF activity across the fetal epicardial gene programme. These findings reveal essential functions for chromatin-remodelling in the activation of EPDCs during cardiovascular development and repair. |*Epigenesis, Genetic [MESH] |*Genes, Wilms Tumor [MESH] |Animals [MESH] |Base Sequence [MESH] |CCAAT-Enhancer-Binding Protein-beta/metabolism [MESH] |Chromatin Assembly and Disassembly [MESH] |Conserved Sequence [MESH] |DNA Helicases/*metabolism [MESH] |Gene Expression Regulation [MESH] |HEK293 Cells [MESH] |Heart/*growth & development [MESH] |Humans [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Myocardial Infarction/metabolism [MESH] |Nuclear Proteins/*metabolism [MESH] |Pericardium/cytology/metabolism [MESH] |Regulatory Elements, Transcriptional [MESH] |Thymosin/*metabolism [MESH]BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape(epmc).pdf DeepDyve Pubget Overpricing