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2017 ; 10
(5
): 1160-1168
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Intestinal helminth infection impacts the systemic distribution and function of
the naive lymphocyte pool
#MMPMID28120841
King IL
; Mohrs K
; Meli AP
; Downey J
; Lanthier P
; Tzelepis F
; Fritz JH
; Tumanov AV
; Divangahi M
; Leadbetter EA
; Mohrs M
Mucosal Immunol
2017[Sep]; 10
(5
): 1160-1168
PMID28120841
show ga
Homeostasis is a fundamental principle of biological systems. A paradigm of
immune homeostasis is the remarkably constant number of naive T and B lymphocytes
in the body that continuously circulate through the secondary lymphoid organs to
maximize immune surveillance. Whether the dynamics and distribution of the
systemic naive lymphocyte pool is affected following organ-specific infection is
not known. Here we show that, following infection of mice with an enteric
helminth, naive T and B lymphocytes accumulate in the T helper type 2-reactive
mesenteric lymph node while they are concurrently depleted from non-draining
peripheral lymph nodes. This systemic redistribution of naive lymphocytes is
sustained into the chronic phase of the infection, requires lymphotoxin beta
receptor-dependent signals and is associated with a reduced ability of
parasitized animals to mount antigen-specific cellular and humoral immune
responses to heterologous immunization or infection at peripheral sites. Our data
suggest that the function of the homeostatic naive lymphocyte pool can be
modulated by its systemic distribution following infection and may provide a
novel concept underlying compromised immune responsiveness at peripheral sites in
helminth-infected individuals.
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