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10.1091/mbc.E16-09-0672 http://scihub22266oqcxt.onion/10.1091/mbc.E16-09-0672 C5526557!5526557!28684608     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Cell 2017 ; 28 (14): 1825-32 Nephropedia Template TP {{tp|p=28684608|t=2017. Dissipation of contractile forces: the missing piece in cell mechanics |pdf=|usr=}}{{28684608}} gab.com Text Dissipation of contractile forces: the missing piece in cell mechanics JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28684608 #FOAvip Mechanical forces are key regulators of cell and tissue physiology. The basic molecular mechanism of fiber contraction by the sliding of actin filament upon myosin leading to conformational change has been known for decades. The regulation of force generation at the level of the cell, however, is still far from elucidated. Indeed, the magnitude of cell traction forces on the underlying extracellular matrix in culture is almost impossible to predict or experimentally control. The considerable variability in measurements of cell-traction forces indicates that they may not be the optimal readout to properly characterize cell contractile state and that a significant part of the contractile energy is not transferred to cell anchorage but instead is involved in actin network dynamics. Here we discuss the experimental, numerical, and biological parameters that may be responsible for the variability in traction force production. We argue that limiting these sources of variability and investigating the dissipation of mechanical work that occurs with structural rearrangements and the disengagement of force transmission is key for further understanding of cell mechanics. Twit Text FOAVip Dissipation of contractile forces: the missing piece in cell mechanics ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28684608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28684608 #FOAvip English Wikipedia <ref>{{Cite pmid|28684608}}</ref> Dissipation of contractile forces: the missing piece in cell mechanics #MMPMID28684608 Kurzawa L; Vianay B; Senger F; Vignaud T; Blanchoin L; Théry M Mol Biol Cell 2017[Jul]; 28 (14): 1825-32 PMID28684608show ga Mechanical forces are key regulators of cell and tissue physiology. The basic molecular mechanism of fiber contraction by the sliding of actin filament upon myosin leading to conformational change has been known for decades. The regulation of force generation at the level of the cell, however, is still far from elucidated. Indeed, the magnitude of cell traction forces on the underlying extracellular matrix in culture is almost impossible to predict or experimentally control. The considerable variability in measurements of cell-traction forces indicates that they may not be the optimal readout to properly characterize cell contractile state and that a significant part of the contractile energy is not transferred to cell anchorage but instead is involved in actin network dynamics. Here we discuss the experimental, numerical, and biological parameters that may be responsible for the variability in traction force production. We argue that limiting these sources of variability and investigating the dissipation of mechanical work that occurs with structural rearrangements and the disengagement of force transmission is key for further understanding of cell mechanics. äDissipation of contractile forces: the missing piece in cell mechanics(epmc).pdf DeepDyve Pubget Overpricing