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10.1016/j.coelec.2017.04.004 http://scihub22266oqcxt.onion/10.1016/j.coelec.2017.04.004 C5526343!5526343!28758153     free     free     free       Curr+Opin+Electrochem 2017 ; 2 (1): 82-7 Nephropedia Template TP {{tp|p=28758153|t=2017. Cell Plasma Membrane Cholesterol as a Diagnostic |pdf=|usr=}}{{28758153}} gab.com Text Cell Plasma Membrane Cholesterol as a Diagnostic JO: Curr Opin Electrochem http://www.kidney.de/pget.php?&tw=1&pmid=28758153 #FOAvip Cholesterol is a tightly regulated major structural component of the cell plasma membrane (PM) where it forms stoichiometric complexes with phospholipids and sphingolipids. The amount of cholesterol in the PM exhibits a regulatory role in basal activity of several biomolecular processes by direct binding to proteins and by indirect local environmental effects within the PM that are also coupled to overall cellular cholesterol homeostasis. The term ?active cholesterol? refers to PM cholesterol not complexed to lipids, a cholesterol state that arises above a threshold mole fraction of cholesterol in the PM. Active cholesterol level in the PM provides a control mechanism for cellular cholesterol homeostasis through its recognition by membrane bound proteins that activate genes of cholesterol synthesis enzymes. Uptake of LDL, production and release of HDL as well as reversible storage of cholesterol in the cytosol by covalent modification are also regulated and dependent on PM cholesterol (thermodynamic) activity: active cholesterol. A number of human disease states have been found to have associated alterations in PM cholesterol and thus a method for its determination is described. Twit Text FOAVip Cell Plasma Membrane Cholesterol as a Diagnostic ????Curr Opin Electrochem http://www.kidney.de/pget.php?&tw=1&pmid=28758153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28758153 #FOAvip English Wikipedia <ref>{{Cite pmid|28758153}}</ref> Cell Plasma Membrane Cholesterol as a Diagnostic #MMPMID28758153 Li L; Lu B; Jiang D; Shin M; Kelley T; Burgess JD Curr Opin Electrochem 2017[Apr]; 2 (1): 82-7 PMID28758153show ga Cholesterol is a tightly regulated major structural component of the cell plasma membrane (PM) where it forms stoichiometric complexes with phospholipids and sphingolipids. The amount of cholesterol in the PM exhibits a regulatory role in basal activity of several biomolecular processes by direct binding to proteins and by indirect local environmental effects within the PM that are also coupled to overall cellular cholesterol homeostasis. The term ?active cholesterol? refers to PM cholesterol not complexed to lipids, a cholesterol state that arises above a threshold mole fraction of cholesterol in the PM. Active cholesterol level in the PM provides a control mechanism for cellular cholesterol homeostasis through its recognition by membrane bound proteins that activate genes of cholesterol synthesis enzymes. Uptake of LDL, production and release of HDL as well as reversible storage of cholesterol in the cytosol by covalent modification are also regulated and dependent on PM cholesterol (thermodynamic) activity: active cholesterol. A number of human disease states have been found to have associated alterations in PM cholesterol and thus a method for its determination is described. äCell Plasma Membrane Cholesterol as a Diagnostic (epmc).pdf DeepDyve Pubget Overpricing