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10.4049/jimmunol.1601999 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601999 C5525333!5525333!28615418     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 199 (2): 397-402 Nephropedia Template TP {{tp|p=28615418|t=2017. Activation of STING in T cells induces type I IFN responses and cell death |pdf=|usr=}}{{28615418}} gab.com Text Activation of STING in T cells induces type I IFN responses and cell death JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28615418 #FOAvip STING was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. Here, we provide the first evidence of STING activation in T cells, in which STING agonists not only provoke IFN-I production and ISG expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways. Our results suggest a reevaluation of STING agonist-based therapies may be necessary to identify possible effects on the T cell compartment. Conversely, the effects of STING on T cells could potentially be harnessed for therapeutic applications. Twit Text FOAVip Activation of STING in T cells induces type I IFN responses and cell death ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28615418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28615418 #FOAvip English Wikipedia <ref>{{Cite pmid|28615418}}</ref> Activation of STING in T cells induces type I IFN responses and cell death #MMPMID28615418 Larkin B; Ilyukha V; Sorokin M; Buzdin A; Vannier E; Poltorak A J Immunol 2017[Jul]; 199 (2): 397-402 PMID28615418show ga STING was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. Here, we provide the first evidence of STING activation in T cells, in which STING agonists not only provoke IFN-I production and ISG expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways. Our results suggest a reevaluation of STING agonist-based therapies may be necessary to identify possible effects on the T cell compartment. Conversely, the effects of STING on T cells could potentially be harnessed for therapeutic applications. äActivation of STING in T cells induces type I IFN responses and cell d(epmc).pdf DeepDyve Pubget Overpricing