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2017 ; 7
(1
): 6318
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English Wikipedia
Multicomponent High-throughput Drug Screening via Inkjet Printing to Verify the
Effect of Immunosuppressive Drugs on Immune T Lymphocytes
#MMPMID28740226
Choi M
; Hwang J
; Choi J
; Hong J
Sci Rep
2017[Jul]; 7
(1
): 6318
PMID28740226
show ga
High-throughput drug screening based on a multi-component array can be used to
identify a variety of interaction between cells and drugs for suitable purposes.
The signaling of immune cells is affected by specific proteins, diverse drug
combinations, and certain immunosuppressive drugs. The effect of a drug on an
organism is usually complex and involves interactions at multiple levels. Herein,
we developed a multilayer fabricating system through the high-throughput assembly
of nanofilms with inkjet printing to investigate the effects of immunosuppressive
drugs. Immunosuppressive drugs or agents occasionally cause side effects
depending on drug combinations or a patient's condition. By incorporating various
drug combinations for understanding interaction between drugs and immune cells,
we were able to develop an immunological drug screening kit with
immunosuppressive drugs. Moreover, the ability to control the combination of
drugs, as well as their potential for high-throughput preparation should be of
great benefit to the biomedical and bioanalytical field.