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2017 ; 7
(1
): 6338
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Updating the list of known opioids through identification and characterization of
the new opioid derivative
3,4-dichloro-N-(2-(diethylamino)cyclohexyl)-N-methylbenzamide (U-49900)
#MMPMID28740128
Fabregat-Safont D
; Carbón X
; Ventura M
; Fornís I
; Guillamón E
; Sancho JV
; Hernández F
; Ibáñez M
Sci Rep
2017[Jul]; 7
(1
): 6338
PMID28740128
show ga
New psychoactive substances have been rapidly growing in popularity in the drug
market as non-illegal drugs. In the last few years, an increment has been
reported on the use of synthetic alternatives to heroin, the synthetic opioids.
Based on the information provided by the European Monitoring Centre for Drug and
Drug Addiction, these synthetic opioids have been related to overdoses and deaths
in Europe and North America. One of these opioids is the U-47700. A few months
ago, U-47700 was scheduled in the U.S. and other countries, and other opioid
derivatives have been appearing in order to replace it. One of these compounds is
U-49900, an analog of U-47700. A white powder sample was obtained from an
anonymous user in Spain. After an accurate characterization by gas
chromatography-mass spectrometry, ultra-high performance liquid
chromatography-high resolution mass spectrometry, nuclear magnetic resonance and
single-crystal X-ray diffraction; and complemented by Fourier-transformed
infrared spectroscopy, ultraviolet and circular dichroism spectrophotometry, the
drug sample was unequivocally identified as U-49900. The information provided
will be useful for the Early Warning System and forensic laboratories for future
identifications of the U-49900, as well as in tentative identifications of other
related opioids.
|Analgesics, Opioid/*analysis/chemistry
[MESH]
|Benzamides/*analysis/chemistry
[MESH]
|Chromatography, High Pressure Liquid/methods
[MESH]