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2017 ; 21
(ä): 9-13
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Predictive and diagnostic value of serum intestinal fatty acid binding protein in
neonatal necrotizing enterocolitis (case series)
#MMPMID28761640
Abdel-Haie OM
; Behiry EG
; Abd Almonaem ER
; Ahmad ES
; Assar EH
Ann Med Surg (Lond)
2017[Sep]; 21
(ä): 9-13
PMID28761640
show ga
OBJECTIVES: In this study, we aimed to investigate the value of serum intestinal
fatty acid binding protein (I-FABP) in early diagnosis and predicting the
severity of Necrotizing enterocolitis (NEC). METHODS: This prospective study was
performed on 160 preterm neonates ageing less than 35 weeks and weighting less
than 2000 gm selected from the Neonatal Intensive Care Units (NICUs) of the
Pediatric Department at Benha University hospital and Benha children hospital to
evaluate which of them will develop NEC, after follow-up these neonates were
divided into two groups: Group one compromised eighteen preterm neonates with
symptoms and signs of NEC. Group two compromised ten preterm neonates as a
control group. All participants were subjected to full clinical examination,
abdominal X-ray and serum I-FABP. RESULTS: The 1st values of IFABP taken at birth
showed that mean serum IFABP concentrations of the study group were higher than
that of the control group. The 2nd values of serum IFABP taken at the start of
feeding showed that mean IFABP concentrations of the study group were higher in
comparison with IFABP at birth. In the 3rd values of serum, IFABP taken at the
time of diagnosing NEC showed that mean serum IFABP concentrations of the study
group were higher than the control group. In the 4th values of serum, IFABP taken
one week after diagnosing NEC showed that the mean serum IFABP concentrations of
the study group became significantly decreased in comparison with IFABP at the
time of diagnosis in stage 1 and 2. CONCLUSIONS: Serial measurements of serum
I-FABP levels may be a useful marker for early diagnosis and prediction of
disease severity in NEC.