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10.1038/ni.3710 http://scihub22266oqcxt.onion/10.1038/ni.3710 C5524187!5524187!28288101     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (5): 530-40 Nephropedia Template TP {{tp|p=28288101|t=2017. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross talks |pdf=|usr=}}{{28288101}} gab.com Text Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross talks JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28288101 #FOAvip Macrophage stimulation with interferon-? (IFN-?) and interleukin 4 (IL-4) triggers distinct and opposing activation programs. During mixed infections or cancer macrophages are often exposed to both cytokines, but how these two programs influence each other remains unclear. We found that IFN-? and IL-4 mutually inhibited epigenomic and transcriptional changes induced by each cytokine alone. Computational and functional analyses revealed the genomic bases for gene-specific cross-repression. For instance, while STAT1 and IRF1 motifs were associated with robust and IL-4-resistant responses to IFN-? their coexistence with binding sites for auxiliary transcription factors such as AP-1, generated vulnerability to IL-4-mediated inhibition. These data provide a core mechanistic framework for the integration of signals that control macrophage activation in complex environmental conditions. Twit Text FOAVip Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross talks ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28288101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28288101 #FOAvip English Wikipedia <ref>{{Cite pmid|28288101}}</ref> Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross talks #MMPMID28288101 Piccolo V; Curina A; Genua M; Ghisletti S; Simonatto M; Sabò A; Amati B; Ostuni R; Natoli G Nat Immunol 2017[May]; 18 (5): 530-40 PMID28288101show ga Macrophage stimulation with interferon-? (IFN-?) and interleukin 4 (IL-4) triggers distinct and opposing activation programs. During mixed infections or cancer macrophages are often exposed to both cytokines, but how these two programs influence each other remains unclear. We found that IFN-? and IL-4 mutually inhibited epigenomic and transcriptional changes induced by each cytokine alone. Computational and functional analyses revealed the genomic bases for gene-specific cross-repression. For instance, while STAT1 and IRF1 motifs were associated with robust and IL-4-resistant responses to IFN-? their coexistence with binding sites for auxiliary transcription factors such as AP-1, generated vulnerability to IL-4-mediated inhibition. These data provide a core mechanistic framework for the integration of signals that control macrophage activation in complex environmental conditions. äOpposing macrophage polarization programs show extensive epigenomic an(epmc).pdf DeepDyve Pubget Overpricing