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10.1038/cddis.2017.248 http://scihub22266oqcxt.onion/10.1038/cddis.2017.248 C5520906!5520906 !28617438     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28617438 &cmd=llinks): Failed to open stream: HTTP request failed! 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Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-?1-dependent activation of Smad/ERK signaling |pdf=|usr=}}{{28617438 }} gab.com Text Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF- 1-dependent activation of Smad/ERK signaling JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28617438 #FOAvip Limited benefits and clinical utility of temozolomide (TMZ) for glioblastoma (GB) are frequently compromised by the development of acquired drug resistance. Overcoming TMZ resistance and uncovering the underlying mechanisms are challenges faced during GB chemotherapy. In this study, we reported that connective tissue growth factor (CTGF) was associated with GB chemoresistance and significantly upregulated in TMZ-treated GB cells. CTGF knockdown promoted TMZ-induced cell apoptosis and enhanced chemosensitivity, whereas its overexpression markedly conferred TMZ resistance in vitro and in vivo. Moreover, CTGF promoted TMZ resistance through stem-like properties acquisition and CD44 interference reversed the CTGF-induced TMZ resistance. Mechanistically, further investigation revealed that the TMZ-induced CTGF upregulation was tissue growth factor (TGF-?) dependent, and regulated by TGF-?1 activation through Smad and ERK1/2 signaling. Together, our results suggest a pivotal role of CTGF-mediated TMZ resistance through TGF-?1-dependent activation of Smad/ERK signaling pathways. These data provide us insights for identifying potential targets that are beneficial for overcoming TMZ resistance in GB. Twit Text FOAVip Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF- 1-dependent activation of Smad/ERK signaling ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28617438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28617438 #FOAvip English Wikipedia <ref>{{Cite pmid|28617438 }}</ref> Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-?1-dependent activation of Smad/ERK signaling #MMPMID28617438 Zeng H ; Yang Z ; Xu N ; Liu B ; Fu Z ; Lian C ; Guo H Cell Death Dis 2017[Jun]; 8 (6 ): e2885 PMID28617438 show ga Limited benefits and clinical utility of temozolomide (TMZ) for glioblastoma (GB) are frequently compromised by the development of acquired drug resistance. Overcoming TMZ resistance and uncovering the underlying mechanisms are challenges faced during GB chemotherapy. In this study, we reported that connective tissue growth factor (CTGF) was associated with GB chemoresistance and significantly upregulated in TMZ-treated GB cells. CTGF knockdown promoted TMZ-induced cell apoptosis and enhanced chemosensitivity, whereas its overexpression markedly conferred TMZ resistance in vitro and in vivo. Moreover, CTGF promoted TMZ resistance through stem-like properties acquisition and CD44 interference reversed the CTGF-induced TMZ resistance. Mechanistically, further investigation revealed that the TMZ-induced CTGF upregulation was tissue growth factor (TGF-?) dependent, and regulated by TGF-?1 activation through Smad and ERK1/2 signaling. Together, our results suggest a pivotal role of CTGF-mediated TMZ resistance through TGF-?1-dependent activation of Smad/ERK signaling pathways. These data provide us insights for identifying potential targets that are beneficial for overcoming TMZ resistance in GB. |*Drug Resistance, Neoplasm [MESH] |Animals [MESH] |Antineoplastic Agents, Alkylating/pharmacology [MESH] |Apoptosis [MESH] |Brain Neoplasms/*drug therapy [MESH] |Cell Line, Tumor [MESH] |Connective Tissue Growth Factor/metabolism [MESH] |Cytokines/metabolism [MESH] |Dacarbazine/*analogs & derivatives/pharmacology [MESH] |Extracellular Signal-Regulated MAP Kinases/*metabolism [MESH] |Flow Cytometry [MESH] |Glioblastoma/*drug therapy [MESH] |Humans [MESH] |Hyaluronan Receptors/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasm Transplantation [MESH] |Signal Transduction/*drug effects [MESH] |Smad Proteins/*metabolism [MESH] |Temozolomide [MESH]Connective tissue growth factor promotes temozolomide resistance in gl(epmc).pdf DeepDyve Pubget Overpricing