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10.1038/cr.2017.36 http://scihub22266oqcxt.onion/10.1038/cr.2017.36 C5520852!5520852!28303890     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2017 ; 27 (5): 642-56 Nephropedia Template TP {{tp|p=28303890|t=2017. Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening |pdf=|usr=}}{{28303890}} gab.com Text Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28303890 #FOAvip Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1? and Gata4 (3TF) to induce hepatic conversion in mouse fibroblasts, we showed that 3TF induced strong activation of the ATM-p53 pathway, which led to proliferation arrest and cell death, and it further prevented hepatic conversion. Notably, ATM activation, independent of DNA damage, responded to chromatin opening during hepatic conversion. By characterizing the early molecular events during hepatic conversion, we found that Baf60b, a member of the SWI/SNF chromatin remodeling complex, links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci. These findings shed light on cellular responses to lineage conversion by revealing a function of the ATM-p53 pathway in sensing chromatin opening. Twit Text FOAVip Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28303890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28303890 #FOAvip English Wikipedia <ref>{{Cite pmid|28303890}}</ref> Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening #MMPMID28303890 Ji S; Zhu L; Gao Y; Zhang X; Yan Y; Cen J; Li R; Zeng R; Liao L; Hou C; Gao Y; Gao S; Wei G; Hui L Cell Res 2017[May]; 27 (5): 642-56 PMID28303890show ga Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1? and Gata4 (3TF) to induce hepatic conversion in mouse fibroblasts, we showed that 3TF induced strong activation of the ATM-p53 pathway, which led to proliferation arrest and cell death, and it further prevented hepatic conversion. Notably, ATM activation, independent of DNA damage, responded to chromatin opening during hepatic conversion. By characterizing the early molecular events during hepatic conversion, we found that Baf60b, a member of the SWI/SNF chromatin remodeling complex, links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci. These findings shed light on cellular responses to lineage conversion by revealing a function of the ATM-p53 pathway in sensing chromatin opening. äBaf60b-mediated ATM-p53 activation blocks cell identity conversion by (epmc).pdf DeepDyve Pubget Overpricing