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10.1038/cddis.2017.138 http://scihub22266oqcxt.onion/10.1038/cddis.2017.138 C5520690!5520690 !28542126     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28542126 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (5 ): e2819 Nephropedia Template TP {{tp|p=28542126 |t=2017. Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/?-catenin/Slug pathway |pdf=|usr=}}{{28542126 }} gab.com Text Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/ -catenin/Slug pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28542126 #FOAvip Mesenchymal stem cells (MSCs) extensively interact with cancer cells and other stroma cells in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) progression and metastasis is controversial. This study was designed to identify the role of inflammation-activated-MSCs in CRC development. Our results show that tumor necrosis factor (TNF)-?-preactivated-hMSCs significantly promote the progression of colon cancer cells by enhancing cell proliferation, epithelial-mesenchymal transition, migration, and invasion. TNF-?-primed-hMSCs secrete high level of CCL5, which interacts with its receptor CCR1 expressed in colon cancer cells. Interestingly, the stimulation of colon cancer cell progression by TNF-?-primed hMSCs is associated with the upregulation of ?-catenin signaling pathway. Blocking ?-catenin pathway significantly decreases the TNF-?-primed-conditioned medium or CCL5-mediated cancer cell progression by decreasing the enhancement of Slug, suggesting that the CCL5/?-catenin/Slug pathway plays a critical role in hMSC-mediated cancer progression. Furthermore, in vivo model in nude mice confirms the ability of hMSCs to promote the proliferation and progression of colon cancer cells, and the upregulation of CCl5/?-catenin/Slug pathway. Taken together, the present study has demonstrated a novel pathway involving CCl5/CCR1/?-catenin/Slug, via which hMSCs promotes CRC development. Twit Text FOAVip Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/ -catenin/Slug pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28542126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28542126 #FOAvip English Wikipedia <ref>{{Cite pmid|28542126 }}</ref> Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/?-catenin/Slug pathway #MMPMID28542126 Chen K ; Liu Q ; Tsang LL ; Ye Q ; Chan HC ; Sun Y ; Jiang X Cell Death Dis 2017[May]; 8 (5 ): e2819 PMID28542126 show ga Mesenchymal stem cells (MSCs) extensively interact with cancer cells and other stroma cells in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) progression and metastasis is controversial. This study was designed to identify the role of inflammation-activated-MSCs in CRC development. Our results show that tumor necrosis factor (TNF)-?-preactivated-hMSCs significantly promote the progression of colon cancer cells by enhancing cell proliferation, epithelial-mesenchymal transition, migration, and invasion. TNF-?-primed-hMSCs secrete high level of CCL5, which interacts with its receptor CCR1 expressed in colon cancer cells. Interestingly, the stimulation of colon cancer cell progression by TNF-?-primed hMSCs is associated with the upregulation of ?-catenin signaling pathway. Blocking ?-catenin pathway significantly decreases the TNF-?-primed-conditioned medium or CCL5-mediated cancer cell progression by decreasing the enhancement of Slug, suggesting that the CCL5/?-catenin/Slug pathway plays a critical role in hMSC-mediated cancer progression. Furthermore, in vivo model in nude mice confirms the ability of hMSCs to promote the proliferation and progression of colon cancer cells, and the upregulation of CCl5/?-catenin/Slug pathway. Taken together, the present study has demonstrated a novel pathway involving CCl5/CCR1/?-catenin/Slug, via which hMSCs promotes CRC development. |*Disease Progression [MESH] |*Epithelial-Mesenchymal Transition/drug effects [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Chemokine CCL5/*metabolism [MESH] |Colorectal Neoplasms/*metabolism/*pathology [MESH] |Humans [MESH] |Mesenchymal Stem Cells/drug effects/*metabolism [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplasm Metastasis [MESH] |Phenotype [MESH] |Receptors, CCR1/metabolism [MESH] |Signal Transduction/drug effects [MESH] |Snail Family Transcription Factors/*metabolism [MESH] |Tumor Necrosis Factor-alpha/pharmacology [MESH]Human MSCs promotes colorectal cancer epithelial-mesenchymal transitio(epmc).pdf DeepDyve Pubget Overpricing